DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6654 and ZNF354B

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_478137.1	Gene:	ZNF354B / 117608	HGNCID:	17197	Length:	612	Species:	Homo sapiens

Alignment Length:	579	Identity:	158/579 - (27%)
Similarity:	227/579 - (39%)	Gaps:	129/579 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 WEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEVFDYELPDEPVEKTTSLILQVQG 174
            ||.::     .:..|::...:....:.|||.:.|...|                       |::.
Human    73 WEVEK-----DSSGVSSLGCKSTPKMTKSTQTQDSFQE-----------------------QIRK 109

  Fly   175 NLK-DEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAK--- 235
            .|| ||.....::.:.|||  :...:||.:..||          :||:|...::.|...:.|
Human   110 RLKRDEPWNFISERSCIYE--EKLKKQQDKNENL----------QIISVAHTKILTVDRSHKNVE 162

  Fly   236 ----------LLTQQENDKHQTPVGSKEEARELEKEQ----VPQSAKRTSRRRGVVKQDVPA-TP 285
                      .:.||...|.:||  ||.|.:....:|    :.||..:|:.:|........| ..
Human   163 FGQNFYLKSVFIKQQRFAKEKTP--SKCEIQRNSFKQNSNLLNQSKIKTAEKRYKCSTCEKAFIH 225

  Fly   286 PSDAEPSPKQHRLGTQRKL----SAPRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMI 346
            .|......|.|   |..||    ...:|.:.:..........|.|..|.|..|...|:...||..
Human   226 NSSLRKHQKNH---TGEKLFKCKECLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCK 287

  Fly   347 HRRQKGCINRNYKCNECEKVFVSPDHLAEHQASHGAHN--------------------------- 384
            |.|.. .:.:.|:|.||.|.|.....|..||..|...|
Human   288 HLRTH-TVEKCYRCKECGKSFSRRSGLFIHQKIHAQENPHKYNPGRKASSYSTSLSGSQKIHLRK 351

  Fly   385 ----CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNIC 445
                |.|||....|..:|..|. :.|......:|:.|.:.|:..::|..|.||||||||:.||.|
Human   352 KSYLCNECGNTFKSSSSLRYHQ-RIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNEC 415

  Fly   446 GKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCS 510
            ||.||..:.|.:|::.|:..|.:.|..|..:..:.:.|..|.|.|||:||.:|:||...|..|.:
Human   416 GKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSA 480

  Fly   511 LAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVC--------------------- 554
            |.:|:|.|||||||.|:.|...|...:.|.||:|.||||:||.|
Human   481 LIQHQRMHTGERPYKCNECDKTFRCNSSLSNHQRIHTGEKPYRCLECGMSFGQSAALIQHQRIHT 545

  Fly   555 ---PF----CSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQHD 606
               ||    |.|||.|......|||.|.||:.|.|..|.:.|.....:.:|...|.:.|
Human   546 GEKPFKCNTCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEED 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/22 (32%)
		COG5048	<357..570	CDD:227381	89/271 (33%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	427..451	CDD:290200	16/23 (70%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	3/16 (19%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	17/51 (33%)
		C2H2 Zn finger	554..574	CDD:275368	11/47 (23%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF354B	NP_478137.1	KRAB	14..73	CDD:214630	158/579 (27%)
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..102		4/30 (13%)
		COG5048	184..596	CDD:227381	127/418 (30%)
		C2H2 Zn finger	188..208	CDD:275368	4/19 (21%)
		C2H2 Zn finger	216..236	CDD:275368	3/19 (16%)
		zf-H2C2_2	228..253	CDD:290200	6/27 (22%)
		C2H2 Zn finger	244..264	CDD:275368	1/19 (5%)
		zf-H2C2_2	256..281	CDD:290200	6/24 (25%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		zf-C2H2	298..320	CDD:278523	9/21 (43%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..340		2/19 (11%)
		C2H2 Zn finger	356..376	CDD:275368	7/20 (35%)
		zf-H2C2_2	368..393	CDD:290200	6/25 (24%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		zf-H2C2_2	396..421	CDD:290200	16/24 (67%)
		C2H2 Zn finger	412..432	CDD:275368	9/19 (47%)
		C2H2 Zn finger	440..460	CDD:275368	5/19 (26%)
		zf-H2C2_2	453..477	CDD:290200	12/23 (52%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..505	CDD:290200	13/24 (54%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		zf-H2C2_2	508..531	CDD:290200	11/22 (50%)
		C2H2 Zn finger	524..544	CDD:275368	1/19 (5%)
		zf-H2C2_2	536..561	CDD:290200	6/24 (25%)
		C2H2 Zn finger	552..572	CDD:275368	8/19 (42%)
		zf-H2C2_2	564..589	CDD:290200	10/24 (42%)
		C2H2 Zn finger	580..600	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000