DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF257

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_258429.2	Gene:	ZNF257 / 113835	HGNCID:	13498	Length:	563	Species:	Homo sapiens

Alignment Length:	327	Identity:	109/327 - (33%)
Similarity:	151/327 - (46%)	Gaps:	56/327 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 ELKYHCDRCNAGF----AVEKSLMIHRRQKGCINRNYKCNECEKVFVSPDHLAEHQASH---GAH 383
            |..:.|:.|...|    |:.:..|.|..:|     .|||.||.|.|....||.:|:..|   ..:
Human   198 ENSHKCEECGKAFNQSSALTRHKMTHTGEK-----PYKCEECGKAFNRSSHLTQHKVIHTREKPY 257

  Fly   384 NCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVF---TMLSTLRDHMRIHTGEKPFVCNIC 445
            .|.|||...:....:::|. :.|.|....:.:.|.|.|   :.|:||..|.||||||||:.|..|
Human   258 KCEECGKAFNRSSHITQHK-RIHNREKPFKYDECCKAFKWSSALTTLTQHKRIHTGEKPYKCEEC 321

  Fly   446 GKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCS 510
            ||:|.|::.|.:||:.|:..|.|:||.|..:|...:.||.|...||.:||::||.|...|..|..
Human   322 GKAFNQSSALTRHKMIHTGEKPFQCEECGKAFNRSSHLTQHKIIHTKEKPYKCEECGKAFNRSSH 386

  Fly   511 LAKHKR-------------------------------KHTGERPYACDLCPMRFTALNVLKNHRR 544
            |.||||                               .||||:||.|:.|...|...:.|..|:.
Human   387 LTKHKRIHTREKAYKCDEYCKAFNWSSALTTLTQHKIIHTGEKPYKCEECGKAFNRSSYLIRHKI 451

  Fly   545 THTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGHEQHDKRL 609
            .||||:||.|..|.|.|.|......|:..|.||:.|.|..|.:.|    ...|||:.|     ::
Human   452 IHTGEKPYKCEECGKAFNQSSHLTQHKIIHTGEKPYKCEECGKAF----NRSSHLSQH-----KI 507

  Fly   610 VH 611
            :|
Human   508 IH 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	88/249 (35%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	8/22 (36%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	19/47 (40%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	10/50 (20%)
		zf-H2C2_2	510..534	CDD:290200	13/54 (24%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
ZNF257	NP_258429.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	<157..474	CDD:227381	96/281 (34%)
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		zf-H2C2_2	215..240	CDD:290200	11/29 (38%)
		C2H2 Zn finger	231..251	CDD:275368	8/19 (42%)
		zf-H2C2_2	243..268	CDD:290200	8/24 (33%)
		C2H2 Zn finger	259..279	CDD:275368	5/20 (25%)
		C2H2 Zn finger	288..310	CDD:275368	8/21 (38%)
		zf-H2C2_2	303..327	CDD:290200	15/23 (65%)
		C2H2 Zn finger	318..338	CDD:275368	9/19 (47%)
		zf-H2C2_2	330..355	CDD:290200	10/24 (42%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		zf-H2C2_2	358..383	CDD:290200	11/24 (46%)
		C2H2 Zn finger	374..394	CDD:275368	10/19 (53%)
		zf-H2C2_2	418..442	CDD:290200	9/23 (39%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		zf-H2C2_2	445..470	CDD:290200	12/24 (50%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		zf-H2C2_2	473..498	CDD:290200	8/28 (29%)
		C2H2 Zn finger	489..509	CDD:275368	7/28 (25%)
		zf-H2C2_2	501..526	CDD:290200	4/14 (29%)
		C2H2 Zn finger	517..537	CDD:275368
		C2H2 Zn finger	545..561	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000