DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF268

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	480	Identity:	137/480 - (28%)
Similarity:	197/480 - (41%)	Gaps:	120/480 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 SAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQH 296
            |.:.||..|:....:.|.|..|..::.           :|:...:|.|.:        ....|.|
Human   287 SKSYLLVHQQTHAEEKPYGCNECGKDF-----------SSKSYLIVHQRI--------HTGEKLH 332

  Fly   297 RLGTQRKLSA--------PRAGTVNGP--------------------STTSGAATTPELKYHCDR 333
            .....||..:        .|..|...|                    .|.||     :..|.|:.
Human   333 ECSECRKTFSFHSQLVIHQRIHTGENPYECCECGKVFSRKDQLVSHQKTHSG-----QKPYVCNE 392

  Fly   334 CNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASH----------------- 380
            |...|.::..|:||.| ..|  .:.|:||||:|.|.:..:|..||.:|
Human   393 CGKAFGLKSQLIIHERIHTG--EKPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTF 455

  Fly   381 --------GAHN----------------------------------CPECGIRCDSKEALSKHMV 403
                    |.|.                                  |.|||....||..|..| .
Human   456 KSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIH-T 519

  Fly   404 QGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSF 468
            :.|.....::||.|.|.|:..|.|..|.||||||.|:.|:.|||:|::...|..|:..|:..|.:
Human   520 RTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPY 584

  Fly   469 KCELCPHSFVTKAELTSHARTHTGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRF 533
            :|..|..:|..|::|..|.|||||:|||||..|...|.|..:|..|:|.||||:||:|:.|...|
Human   585 ECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAF 649

  Fly   534 TALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKS----MPE 594
            |..:.|..|:..|||.:||.|..|:|||:.:....:|||:|.|.:.|.|..|.:.|:|    :..
Human   650 TFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIH 714

  Fly   595 MRSHLAGHEQHDKRLVHFTFLSNKE 619
            ||:| .|.:.|:.|....:|..|.:
Human   715 MRTH-TGEKPHECRECGKSFSFNSQ 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	90/271 (33%)
		C2H2 Zn finger	360..380	CDD:275368	9/19 (47%)
		C2H2 Zn finger	385..406	CDD:275370	8/20 (40%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	14/23 (61%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	14/24 (58%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	7/23 (30%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368	4/10 (40%)
		C2H2 Zn finger	306..326	CDD:275368	4/38 (11%)
		C2H2 Zn finger	334..354	CDD:275368	3/19 (16%)
		zf-H2C2_2	347..371	CDD:290200	3/23 (13%)
		C2H2 Zn finger	362..382	CDD:275368	0/19 (0%)
		zf-H2C2_2	375..397	CDD:290200	6/26 (23%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..427	CDD:290200	12/25 (48%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		zf-H2C2_2	430..454	CDD:290200	4/23 (17%)
		C2H2 Zn finger	446..466	CDD:275368	1/19 (5%)
		C2H2 Zn finger	474..494	CDD:275368	0/19 (0%)
		COG5048	497..910	CDD:227381	95/244 (39%)
		C2H2 Zn finger	502..522	CDD:275368	8/20 (40%)
		C2H2 Zn finger	530..550	CDD:275368	9/19 (47%)
		zf-H2C2_2	543..567	CDD:290200	14/23 (61%)
		zf-C2H2	556..578	CDD:278523	7/21 (33%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..606	CDD:275368	7/19 (37%)
		zf-H2C2_2	599..623	CDD:290200	14/23 (61%)
		C2H2 Zn finger	614..634	CDD:275368	7/19 (37%)
		zf-H2C2_2	626..650	CDD:290200	11/23 (48%)
		C2H2 Zn finger	642..662	CDD:275368	6/19 (32%)
		C2H2 Zn finger	670..690	CDD:275368	8/19 (42%)
		C2H2 Zn finger	698..718	CDD:275368	6/19 (32%)
		zf-H2C2_2	710..734	CDD:290200	6/24 (25%)
		C2H2 Zn finger	726..746	CDD:275368	3/13 (23%)
		zf-H2C2_2	739..763	CDD:290200	137/480 (29%)
		C2H2 Zn finger	754..774	CDD:275368
		C2H2 Zn finger	782..802	CDD:275368
		zf-H2C2_2	794..817	CDD:290200
		C2H2 Zn finger	810..830	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		zf-H2C2_2	851..875	CDD:290200
		C2H2 Zn finger	866..886	CDD:275368
		C2H2 Zn finger	894..914	CDD:275368
		zf-H2C2_2	907..929	CDD:290200
		C2H2 Zn finger	922..942	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910