DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF273

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_066971.2	Gene:	ZNF273 / 10793	HGNCID:	13067	Length:	569	Species:	Homo sapiens

Alignment Length:	433	Identity:	134/433 - (30%)
Similarity:	185/433 - (42%)	Gaps:	74/433 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 DDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQEND----KHQTPVGSKEE 254
            |:|::.::          |.:...:.:|.|..::.......|:|.:..|.    |.||  |.|
Human   154 DEHKVHKR----------GYNGLNQCLTTTQSKIFQCDKYVKVLHKFSNSNIHKKRQT--GKK-- 204

  Fly   255 ARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAPRAGTVNGPSTTS 319
                     |...|...:...::.|                   .||.|.:|.|.....  ..|.
Human   205 ---------PFKCKECGKSCCILSQ-------------------LTQHKKTATRVNFYK--CKTC 239

  Fly   320 GAATT------------PELK-YHCDRC----NAGFAVEKSLMIHRRQKGCINRNYKCNECEKVF 367
            |.|..            ||:. |.|:.|    |....:.|...||..:|     .|||.:|.|||
Human   240 GKAFNQFSNLTKHKIIHPEVNPYKCEECGKAFNQSLTLTKHKKIHTEEK-----PYKCEDCGKVF 299

  Fly   368 VSPDHLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRD 429
            .....|.:|:..|..   :||.|||........|:||.:. |......:||.|.|.|...|||..
Human   300 SVFSVLTKHKIIHTGTKPYNCEECGKGFSIFSTLTKHKII-HTGEKPYKCNECGKAFNWSSTLTK 363

  Fly   430 HMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDK 494
            |.||||||||:.|..|||:|.|::.|.:||:.|:..|.:|||.|..:|.....||.|.|.:|.:|
Human   364 HKRIHTGEKPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKHKRIYTKEK 428

  Fly   495 PFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSK 559
            |::||.|...|:...:|.|||..|||.:||.|:.|...|.|.:.|..|:|.||||:||.|..|.|
Human   429 PYKCEECGKAFSVFSTLTKHKIIHTGAKPYKCEECGSAFRAFSTLTEHKRVHTGEKPYKCNECGK 493

  Fly   560 TFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH 602
            .|........|:|.|.||:.|.|..|.:.|.....:..|...|
Human   494 AFNWSSTLTKHKRIHTGEKPYKCEECGKAFNRSSNLTRHKKIH 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	7/26 (27%)
		COG5048	<357..570	CDD:227381	89/215 (41%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	15/23 (65%)
		C2H2 Zn finger	442..490	CDD:275368	20/47 (43%)
		C2H2 Zn finger	470..487	CDD:275368	6/16 (38%)
		zf-H2C2_2	482..507	CDD:290200	11/24 (46%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF273	NP_066971.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		KRAB	37..97	CDD:214630
		KRAB	37..76	CDD:279668
		COG5048	191..537	CDD:227381	127/386 (33%)
		C2H2 Zn finger	208..228	CDD:275368	5/38 (13%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		C2H2 Zn finger	264..284	CDD:275368	4/19 (21%)
		zf-H2C2_2	277..300	CDD:290200	10/27 (37%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		C2H2 Zn finger	320..340	CDD:275368	7/20 (35%)
		zf-H2C2_2	333..356	CDD:290200	8/23 (35%)
		C2H2 Zn finger	348..368	CDD:275368	10/19 (53%)
		zf-H2C2_2	361..385	CDD:290200	15/23 (65%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..413	CDD:290200	10/23 (43%)
		C2H2 Zn finger	404..423	CDD:275368	7/18 (39%)
		zf-H2C2_2	417..440	CDD:290200	10/22 (45%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		zf-H2C2_2	473..496	CDD:290200	12/22 (55%)
		C2H2 Zn finger	488..508	CDD:275368	6/19 (32%)
		zf-H2C2_2	501..525	CDD:290200	9/23 (39%)
		C2H2 Zn finger	516..536	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..569		1/1 (100%)
		C2H2 Zn finger	544..564	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000