DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6654 and ZBTB18

DIOPT Version :9

Sequence 1:NP_650429.1 Gene:CG6654 / 41831 FlyBaseID:FBgn0038301 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_991331.1 Gene:ZBTB18 / 10472 HGNCID:13030 Length:531 Species:Homo sapiens


Alignment Length:548 Identity:118/548 - (21%)
Similarity:184/548 - (33%) Gaps:184/548 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DVDKICLTCL-----------------SSTGPLLSIYDGGSGSCLADMIREFTKTKPRRNDNLPE 49
            |:.|:|...|                 ||....:.....||.....|:..:..:.:..:.:.||.
Human   117 DIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPS 181

  Fly    50 KVCLSCLSEISNCYTFKIKCENSSRTLRQLLPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDR 114
            |..|:  :|..|.:   ::..:.|..:.|....|.|....:..:::.|.::|:...|       |
Human   182 KRDLA--AEPGNMW---MRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQ-------R 234

  Fly   115 CTASVQTDAVTTTDAEQNTSLIKSTIS----VDLDYEGEGEVFDYELPDEPVEKTTSLILQVQGN 175
            ...||:..|  ..|...:.| :||::|    ::..|....:|....|....|||..|.       
Human   235 SVTSVRDSA--DVDCVLDLS-VKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASC------- 289

  Fly   176 LKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQ 240
              ||.:|   .||      |:::|..                          |.::|.:.....|
Human   290 --DESDV---GTN------DYDMEHS--------------------------TVKESVSTNNRVQ 317

  Fly   241 ENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLS 305
            ....|..|:......|||::|.             ....|...||.|:.    .|...|.:..| 
Human   318 YEPAHLAPLREDSVLRELDRED-------------KASDDEMMTPESER----VQVEGGMESSL- 364

  Fly   306 APRAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNECEKVFVSP 370
            .|....:..|:                                      .:.:.|..|.|||.||
Human   365 LPYVSNILSPA--------------------------------------GQIFMCPLCNKVFPSP 391

  Fly   371 DHLAEHQASHGAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHT 435
            ..|..|.::|...   :.|||  ||.|...::         ..|::|.|.|:.:.||:.|.|.|:
Human   392 HILQIHLSTHFRE---QDGIR--SKPAADVNV---------PTCSLCGKTFSCMYTLKRHERTHS 442

  Fly   436 GEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEV 500
            ||||:.|..|||||..:.|                            |:.||..||.:||..|:.
Human   443 GEKPYTCTQCGKSFQYSHN----------------------------LSRHAVVHTREKPHACKW 479

  Fly   501 CLARFTTSCSLAKHKRKHTGERPYACDL 528
            |..|||.|..|.:|.||      :.|:|
Human   480 CERRFTQSGDLYRHIRK------FHCEL 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6654NP_650429.1 zf-AD 6..79 CDD:285071 14/89 (16%)
C2H2 Zn finger 331..354 CDD:275368 0/22 (0%)
COG5048 <357..570 CDD:227381 55/172 (32%)
C2H2 Zn finger 360..380 CDD:275368 9/19 (47%)
C2H2 Zn finger 385..406 CDD:275370 6/20 (30%)
C2H2 Zn finger 414..434 CDD:275368 8/19 (42%)
zf-H2C2_2 427..451 CDD:290200 14/23 (61%)
C2H2 Zn finger 442..490 CDD:275368 10/47 (21%)
C2H2 Zn finger 470..487 CDD:275368 1/16 (6%)
zf-H2C2_2 482..507 CDD:290200 11/24 (46%)
C2H2 Zn finger 498..518 CDD:275368 9/19 (47%)
zf-H2C2_2 510..534 CDD:290200 6/19 (32%)
C2H2 Zn finger 526..546 CDD:275368 2/3 (67%)
zf-H2C2_2 539..563 CDD:290200
C2H2 Zn finger 554..574 CDD:275368
C2H2 Zn finger 582..602 CDD:275368
ZBTB18NP_991331.1 BTB 23..119 CDD:279045 1/1 (100%)
BTB 34..119 CDD:197585 1/1 (100%)
COG5048 <303..>490 CDD:227381 67/310 (22%)
C2H2 Zn finger 381..401 CDD:275368 9/19 (47%)
C2H2 Zn finger 421..441 CDD:275368 8/19 (42%)
zf-H2C2_2 434..456 CDD:290200 12/21 (57%)
C2H2 Zn finger 449..469 CDD:275368 10/47 (21%)
C2H2 Zn finger 477..495 CDD:275368 8/17 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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