DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF443

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_005806.3	Gene:	ZNF443 / 10224	HGNCID:	20878	Length:	671	Species:	Homo sapiens

Alignment Length:	335	Identity:	110/335 - (32%)
Similarity:	154/335 - (45%)	Gaps:	42/335 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 TPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPDHLAEHQASHGA---HN 384
            |.|..|.|.:|:..|....|.:||.| ..|  .:.|.|.:|.|.|.....|..|:.:|.|   :.
Human   276 TGEKPYKCKQCSKAFPDSSSCLIHERTHTG--EKPYTCKQCGKAFSVSGSLQRHETTHSAEKPYA 338

  Fly   385 CPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSF 449
            |.:||.......:..:||:: |..|..::|.||.|.|...|:|:.|.|.||||||:.|..|||:.
Human   339 CQQCGKAFHHLGSFQRHMIR-HTGNGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGKAL 402

  Fly   450 TQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFECEVC---------LARF 505
            :..::.|.|.:.|:.....||::|..:||..:....|.||||.:||::|:.|         |.|.
Human   403 SHRSSFRSHMIMHTGDGPHKCKVCGKAFVYPSVFQRHERTHTAEKPYKCKQCGKAYRISSSLRRH 467

  Fly   506 TTS------------------CSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPY 552
            .|:                  ||...||..||||:||.|..|...|:....|..|:||||||:||
Human   468 ETTHTGEKPYKCKLGKACIDFCSFQNHKTTHTGEKPYECKECGKAFSRFRYLSRHKRTHTGEKPY 532

  Fly   553 VCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEFKSMPEMRSHLAGH--------EQHDKRL 609
            .|..|.|.|....:.::|:|.|.||:.|.|..|.:.|..:.....|...|        .|..|..
Human   533 ECKTCRKAFGHYDNLKVHERIHSGEKPYECKECGKAFSWLTCFLRHERIHMREKSYECPQCGKAF 597

  Fly   610 VHFTFLSNKE 619
            .|..||...|
Human   598 THSRFLQGHE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	8/23 (35%)
		COG5048	<357..570	CDD:227381	82/242 (34%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..406	CDD:275370	5/20 (25%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	14/47 (30%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	11/33 (33%)
		C2H2 Zn finger	498..518	CDD:275368	9/46 (20%)
		zf-H2C2_2	510..534	CDD:290200	11/23 (48%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	14/23 (61%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	4/19 (21%)
ZNF443	NP_005806.3	KRAB	3..43	CDD:307490
		C2H2 Zn finger	133..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		COG5048	196..579	CDD:227381	102/305 (33%)
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..247	CDD:275368
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	5/20 (25%)
		C2H2 Zn finger	367..387	CDD:275368	9/19 (47%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	6/19 (32%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		C2H2 Zn finger	562..582	CDD:275368	4/19 (21%)
		C2H2 Zn finger	590..610	CDD:275368	6/18 (33%)
		C2H2 Zn finger	618..638	CDD:275368
		C2H2 Zn finger	651..671	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910