DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF783

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_011514003.1	Gene:	ZNF783 / 100289678	HGNCID:	27222	Length:	557	Species:	Homo sapiens

Alignment Length:	632	Identity:	137/632 - (21%)
Similarity:	195/632 - (30%)	Gaps:	200/632 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LPNALPEEPDSKVSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDL 144
            ||....|:.....|....:.|...|:|....:.|.|...:.|....|..||:..:..:.| :|:.
Human    36 LPQPAAEKNSYLYSTEITLWTVVAAIQALEKKVDSCLTRLLTLEGRTGTAEKKLADCEKT-AVEF 99

  Fly   145 DYEGEGE-------VFDYELPDEPVEKTTSL-------ILQVQGNLKDEK---EVVFTQTNVIY- 191
            ..:.||:       :.:|.|....:|...:|       ||::....|.|.   .|.|....|.:
Human   100 GNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGEAPKVPVTFDDVAVYFS 164

  Fly   192 -------EGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDKHQTPV 249
                   |....||.:.:...|......:|     ..::.|.:.||           .::.:.|.
Human   165 ELEWGKLEDWQKELYKHVMRGNYETLVSLD-----YAISKPDILTR-----------IERGEEPC 213

  Fly   250 ---GSKEEARELEKEQVPQSAKRTSRRRGVVKQDVP---ATPPSDAEPSPKQHRLGTQRKLSAPR 308
               ..:|:..|:|..:        .|..|......|   .:|.|.|:...|:.:...|::.|..|
Human   214 LDRWGQEKGNEVEVGR--------PRMMGTGLPPYPEHLTSPLSPAQEELKEGQAPKQQQDSEAR 270

  Fly   309 AGTVNGPSTTSGAA----------TTPELKYHCDRCNAGFAVEKSLMIHRRQKGCINRNYKCNEC 363
            .... ||....|.|          .|||..:              |.:.|.|..|
Human   271 VAPA-GPEAGGGVAIKTEAQSEDEMTPERLF--------------LGVSRGQTEC---------- 310

  Fly   364 EKVFVSPDHLAEHQASHGAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLR 428
                         :...|..|.|         ...|:|..||..
Human   311 -------------RIPRGPRNRP---------GGPSRHQAQGMP--------------------- 332

  Fly   429 DHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHT-- 491
               |:..|| |......|::....:..||        ::|.|..|..||..|..||.|.|||.
Human   333 ---RVRAGE-PRPPGASGETPRVLSRRRQ--------RAFPCPDCGQSFRLKINLTIHQRTHVEE 385

  Fly   492 ------GDKPFEC----------EVCL-------------ARFTTSCSLAKHKRKHTGERPYACD 527
                  |..|..|          ||.:             .|.:.:...|...|:....:.|.|.
Human   386 GRQEAPGRSPTSCGDSQAMLEPGEVVVPGPVIRWLPEEPEGRRSVAGGRALVGRRPAASKMYHCS 450

  Fly   528 LCPMRFTALNVLKNHRRTHTGER---PYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVCNEEF 589
            .|...|.....|..|:|.|||..   | .||:|.|.|.:..|...|||.|.|||.|.||.|...|
Human   451 ECLRFFQQRKSLLLHQRLHTGNGQGWP-ACPYCGKAFRRPSDLFRHQRIHTGERPYQCPQCGRTF 514

  Fly   590 KSMPEMRSHLAGHEQ-HDKRLV--HF------------TFLSNKENG 621
                ....|||.|.| |.:..|  ||            .:.|.||.|
Human   515 ----NRNHHLAVHMQTHARGQVGPHFPAAPARHGSLPLPWPSRKEEG 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	3/22 (14%)
		COG5048	<357..570	CDD:227381	51/246 (21%)
		C2H2 Zn finger	360..380	CDD:275368	0/19 (0%)
		C2H2 Zn finger	385..406	CDD:275370	4/20 (20%)
		C2H2 Zn finger	414..434	CDD:275368	1/19 (5%)
		zf-H2C2_2	427..451	CDD:290200	5/23 (22%)
		C2H2 Zn finger	442..490	CDD:275368	13/47 (28%)
		C2H2 Zn finger	470..487	CDD:275368	7/16 (44%)
		zf-H2C2_2	482..507	CDD:290200	12/55 (22%)
		C2H2 Zn finger	498..518	CDD:275368	6/42 (14%)
		zf-H2C2_2	510..534	CDD:290200	5/23 (22%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/26 (46%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
ZNF783	XP_011514003.1	DUF3669	68..123	CDD:289202	12/55 (22%)
		KRAB	154..213	CDD:214630	11/74 (15%)
		KRAB_A-box	154..193	CDD:143639	7/38 (18%)
		zf-C2H2	360..382	CDD:278523	10/21 (48%)
		C2H2 Zn finger	362..382	CDD:275370	9/19 (47%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		COG5048	479..>527	CDD:227381	23/51 (45%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-C2H2	479..499	CDD:278523	9/19 (47%)
		zf-H2C2_2	491..516	CDD:290200	13/28 (46%)
		C2H2 Zn finger	507..527	CDD:275368	9/23 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000