DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6654 and ZNF717

DIOPT Version :9

Sequence 1:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_011531546.1	Gene:	ZNF717 / 100131827	HGNCID:	29448	Length:	948	Species:	Homo sapiens

Alignment Length:	468	Identity:	146/468 - (31%)
Similarity:	201/468 - (42%)	Gaps:	88/468 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIITVTAPQVTTRKSAAKLLTQQENDK 244
            |.|...||    .|..:|.|   :.||        |.|.|:     ||.|:........:.:..|
Human   262 KRVHIVQT----FGKYNEYE---KACN--------NSAVIV-----QVITQVGQPTCCRKSDFTK 306

  Fly   245 H-QTPVGSKE-EARELEKEQVPQSAKRTSRRRGVVKQDVPATPPSDAEPSPKQHRLGTQRKLSAP 307
            | ||..|.|. |..|.||                              ||..:..|..|.|:
Human   307 HQQTHTGEKPYECVECEK------------------------------PSISKSDLMLQCKM--- 338

  Fly   308 RAGTVNGPSTTSGAATTPELKYHCDRCNAGFAVEKSLMIHRR-QKGCINRNYKCNECEKVFVSPD 371
                           .|.|..|.|:.|...|:.:.||:||:| ..|  .:.|.||||.|.|....
Human   339 ---------------PTEEKPYACNWCEKLFSYKSSLIIHQRIHTG--EKPYGCNECGKTFRRKS 386

  Fly   372 HLAEHQASHGA---HNCPECGIRCDSKEALSKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRI 433
            .|..|:.:|..   :.|.|||.....|..|:.|. :.|......||:.|.|.|:..|.|..|.|.
Human   387 FLTLHERTHTGDKPYKCIECGKTFHCKSLLTLHH-RTHSGEKPYQCSECGKTFSQKSYLTIHHRT 450

  Fly   434 HTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELTSHARTHTGDKPFEC 498
            ||||||:.|:.|.::|:..:.|..|:..|:..|.::|..|...|:.|:.|..|.|||||:||:||
Human   451 HTGEKPYACDHCEEAFSHKSRLTVHQRTHTGEKPYECNECGKPFINKSNLRLHQRTHTGEKPYEC 515

  Fly   499 EVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQ 563
            ..|...|.....|..|:..||||:||.|:.|...|...:.|..|:|||.||:||.|..|.||::.
Human   516 NECGKTFHRKSFLTIHQWTHTGEKPYECNECGKTFRCKSFLTVHQRTHAGEKPYACNECGKTYSH 580

  Fly   564 RGDCQMHQRTHQGERIYICPVCNEEF--KSM--PEMRSHLAGHEQHDKRLVHFTFLS------NK 618
            :....:|.|||.||:.|.|..|.:.|  ||.  ...|:| ||.:.::......||::      :|
Human   581 KSYLTVHHRTHTGEKPYECNECGKSFHCKSFLTIHQRTH-AGKKPYECNECEKTFINKLNLGIHK 644

  Fly   619 ENGSGALEEELNE 631
            ...:|....|.||
Human   645 RTHTGERPYECNE 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071
		C2H2 Zn finger	331..354	CDD:275368	9/23 (39%)
		COG5048	<357..570	CDD:227381	81/215 (38%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..406	CDD:275370	7/20 (35%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
		zf-H2C2_2	427..451	CDD:290200	12/23 (52%)
		C2H2 Zn finger	442..490	CDD:275368	14/47 (30%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	13/24 (54%)
		C2H2 Zn finger	498..518	CDD:275368	5/19 (26%)
		zf-H2C2_2	510..534	CDD:290200	10/23 (43%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	13/23 (57%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	8/23 (35%)
ZNF717	XP_011531546.1	KRAB	56..116	CDD:214630
		KRAB	56..95	CDD:279668
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	343..723	CDD:227381	114/319 (36%)
		C2H2 Zn finger	347..367	CDD:275368	8/19 (42%)
		C2H2 Zn finger	375..395	CDD:275368	8/19 (42%)
		zf-H2C2_2	388..412	CDD:290200	7/23 (30%)
		C2H2 Zn finger	403..423	CDD:275368	7/20 (35%)
		zf-H2C2_2	416..440	CDD:290200	8/24 (33%)
		zf-C2H2	429..451	CDD:278523	9/21 (43%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		zf-H2C2_2	443..468	CDD:290200	12/24 (50%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		zf-H2C2_2	472..494	CDD:290200	6/21 (29%)
		C2H2 Zn finger	487..507	CDD:275368	7/19 (37%)
		zf-H2C2_2	499..524	CDD:290200	13/24 (54%)
		C2H2 Zn finger	515..535	CDD:275368	5/19 (26%)
		zf-H2C2_2	528..552	CDD:290200	11/23 (48%)
		C2H2 Zn finger	543..563	CDD:275368	6/19 (32%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		zf-H2C2_2	583..608	CDD:290200	10/24 (42%)
		COG5048	595..932	CDD:227381	17/64 (27%)
		C2H2 Zn finger	599..619	CDD:275368	6/19 (32%)
		C2H2 Zn finger	627..647	CDD:275368	3/19 (16%)
		zf-H2C2_2	639..664	CDD:290200	5/19 (26%)
		C2H2 Zn finger	655..675	CDD:275368	2/3 (67%)
		zf-H2C2_2	667..692	CDD:290200
		C2H2 Zn finger	683..703	CDD:275368
		zf-H2C2_2	779..801	CDD:290200
		C2H2 Zn finger	794..814	CDD:275368
		C2H2 Zn finger	822..842	CDD:275368
		zf-H2C2_2	835..859	CDD:290200
		C2H2 Zn finger	850..870	CDD:275368
		zf-H2C2_2	863..887	CDD:290200
		C2H2 Zn finger	878..898	CDD:275368
		zf-H2C2_2	891..913	CDD:290200
		zf-C2H2	904..926	CDD:278523
		C2H2 Zn finger	906..926	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910