DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and SERPINA6

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	425	Identity:	100/425 - (23%)
Similarity:	185/425 - (43%)	Gaps:	58/425 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TIAALDKPELSFLNEFSQIFKG----ERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSS 76
            |:.|:| |..:::| .|...:|    ..||:.:|.|.:..:.|..|:|.||.|...||.:....:
Human    19 TVQAMD-PNAAYVN-MSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGT 81

  Fly    77 SEQTERELAQALNLGWALNKQQVLVSYTLAQRQDE------------FRWRQSPMELSSANRIFV 129
            ...|..:|.|.|             .:.|.:|.:.            |....:.:|::..|.:|:
Human    82 CGHTRAQLLQGL-------------GFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFL 133

  Fly   130 DRTINVSNKFNTLL--YGATKELDFK-NDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLV 191
            |.::.:...|:..:  |..::.|... .|..|..::||.::.:||..:|.|:.|.  :....:||
Human   134 DGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSG--LDSPAILV 196

  Fly   192 LANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIY 256
            |.|..:.||.|...|.:..|..:.|:::|.....|.||.::.......|..|..|::::.|
Human   197 LVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNY---- 257

  Fly   257 KSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQKIELSLPKFQFEQ 321
                        ..:.::..|||:..|  :|.||:.|:.|::.:|.......:::|.:||.....
Human   258 ------------VGNGTVFFILPDKGK--MNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISG 308

  Fly   322 RLELTPILSLMGVNTMFTRNATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSS 386
            ..:|..:|..||:..:||..|.|..:|.| ..|......|.|.::::|.|...|.:|.:.::.:|
Human   309 VYDLGDVLEEMGIADLFTNQANFSRITQD-AQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTS 372

  Fly   387 RQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDP 421
            :   |.....|.||:.:|:|....:.||.....:|
Human   373 K---PIILRFNQPFIIMIFDHFTWSSLFLARVMNP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	93/399 (23%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	92/395 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020