DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and Serpind1

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	106/410 - (25%)
Similarity:	185/410 - (45%)	Gaps:	49/410 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QIFKGE----------RDFSLALMKQIR-EIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQ 86
            |:|:|:          ..|:..|.:.:: :...|.|:|.:|.....|:.:.......:|..|:..
  Rat    95 QLFQGKSRIQRLNILNAKFAFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHS 159

  Fly    87 ALNLGWALN---KQQVLVSYTLAQRQDE--FRWRQSPMELSSANRIFVDRTINVSNKFNTLL--- 143
            .|:....:|   |.:|...:.|.::...  || |.....|.|.|.:::.:...:...|...:
  Rat   160 VLHFKDFVNASSKYEVTTIHNLFRKLTHRLFR-RNFGYTLQSVNDLYIQKQFPIREDFKAAMREF 223

  Fly   144 -YGATKELDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFK 207
             :...:|.|| :|| ..:.:.|..|...|...|::.|  |.....|.:::.|..|.||.|:::|.
  Rat   224 YFAEAQEADF-SDP-AFISKANSHILKLTKGLIKEAL--ENTDSATQMMILNCIYFKGAWMNKFP 284

  Fly   208 VEETALKPFFINEREQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDI 272
            ||.|....|.:||||...|.||...|.|....|:.|...|::|.|                ...|
  Rat   285 VEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY----------------VGGI 333

  Fly   273 SMIIILPNSNKIS-LNRVISRLNADSVKKWFERALPQKIELSLPKFQFEQRLELTPILSLMGVNT 336
            ||:|::|  .|:| :..:.::|....|::|.:....:..|:.||||:.|:...|..:|..||:..
  Rat   334 SMLIVIP--RKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITK 396

  Fly   337 MFTRNATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFV 401
            :|.:|.....::...|  :||..:|.:.|.|:|.|:.|||.|.:.....|.|   .:|..:.||:
  Rat   397 LFNKNGNMSGISDQRI--IIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQ---VRFTVDRPFL 456

  Fly   402 FLIYDEKVDTILFAGVYSDP 421
            ||:|:.:...:||.|..::|
  Rat   457 FLVYEHRTSCLLFMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	103/401 (26%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	106/410 (26%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110