DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and SERPINB4

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	415	Identity:	119/415 - (28%)
Similarity:	201/415 - (48%)	Gaps:	46/415 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LNEFSQIFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGW 92
            :|..|:   ....|...|.:|.|: ....|:|:||.|..:||.:....:.:.|.:::::.|:...
Human     1 MNSLSE---ANTKFMFDLFQQFRK-SKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQ 61

  Fly    93 AL-NKQQVLVSYTLAQRQD----------EFRWRQSPMELSSANRIFVDRT-------INVSNKF 139
            .. |..:...:|.:.:..:          ||.......||..||::|.::|       ::...||
Human    62 VTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKF 126

  Fly   140 NTLLYGATKE-LDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWL 203
                |..:.| .||.|.||...|:||.|:..:|:.:|:::.....|...|.|||.||.|.||||.
Human   127 ----YQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWE 187

  Fly   204 SQFKVEETALKPFFINEREQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPES 268
            ::||.|.|..:.|:.|:...:.|.||.:..:|...:.|.:|::::::|    ||.|
Human   188 NKFKKENTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIP----YKGK--------- 239

  Fly   269 KSDISMIIILPNSNKISLNRVISRLNADSVKKW--FERALPQKIELSLPKFQFEQRLELTPILSL 331
              |:|||::|||... .|.::..:|.|:.:.:|  .:......::|.||:|:.|:..:|...|..
Human   240 --DLSMIVLLPNEID-GLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRT 301

  Fly   332 MGVNTMFTRNATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNC 396
            ||:..:|..:|....:|... .|.:....|.|.::|.|.|..|||||.::|...|......:|.|
Human   302 MGMVNIFNGDADLSGMTWSH-GLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCC 365

  Fly   397 NHPFVFLIYDEKVDTILFAGVYSDP 421
            ||||:|.|...|.::|||.|.:|.|
Human   366 NHPFLFFIRQNKTNSILFYGRFSSP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	115/401 (29%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	117/410 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920