DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and serpinf2b

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001073479.1	Gene:	serpinf2b / 563663	ZFINID:	ZDB-GENE-061215-114	Length:	479	Species:	Danio rerio

Alignment Length:	396	Identity:	102/396 - (25%)
Similarity:	188/396 - (47%)	Gaps:	55/396 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNKQQ 98
            |..|.....|..::.::......|:.|||.|...||......::..||..|...|:       ..
Zfish   104 IGNGIMKLGLLFLENLKPSPDQPNVIFSPLSLSVALSQLALGATNDTEELLLHHLH-------AD 161

  Fly    99 VLVSY--TLAQRQDEFRWRQSPMELSSANRIFVDRTINVSNKFNTLLYGATKELDFKNDPETGLK 161
            .|..|  .|:.....||.|..|:    |:||::.......:.|   :..:.|..|.:....|.:.
Zfish   162 ALPCYHTALSSLLRNFRKRSMPI----ASRIYLKTGFKAKSDF---MEDSQKLYDSEPATLTDVN 219

  Fly   162 EINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQEMV 226
            ::|:|:...|:..|.:.|||  :.|..:::|.||.:.||:||::|....|:.:.|:|:|.:...|
Zfish   220 DVNEWVKKVTNGHISEFLSS--LPPSAVMMLINAMHYKGEWLTRFDPHFTSTENFYIDENQIVNV 282

  Fly   227 YMM----HKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLN 287
            .||    :....|  |..| |.:|:.:.|:                |.|.|:::::|.|..::::
Zfish   283 DMMLGPKYPLSVF--THHE-LDAQVARFPF----------------KGDRSLLVVMPTSGHVNVS 328

  Fly   288 RVISRLNADSVKKWFERALPQK--IELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLTAD 350
            .:.::||   :...:.| ||::  :::.||||:.:...:|...::.||:..:|: :.....:|..
Zfish   329 AIAAKLN---ISDLYSR-LPRERNMQVKLPKFKLDFNQDLQEAMTSMGLGKLFS-HPKLDRITEG 388

  Fly   351 PISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFA 415
            |  |.:...||::.::::|.|:.|.|||.:::|||:     ..|..|.||.|.:.|:...|.||.
Zfish   389 P--LFVSSVQHMSSVEINEEGAEAVAATSVVISRSN-----PSFTVNQPFFFALMDDLSQTPLFL 446

  Fly   416 GVYSDP 421
            ||.|:|
Zfish   447 GVISNP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	98/388 (25%)
serpinf2b	NP_001073479.1	SERPIN	106..449	CDD:294093	98/389 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100