DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and SERPINA4

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001275961.1	Gene:	SERPINA4 / 5267	HGNCID:	8948	Length:	464	Species:	Homo sapiens

Alignment Length:	471	Identity:	112/471 - (23%)
Similarity:	178/471 - (37%)	Gaps:	97/471 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHTFSLVLLALLPVVTIAALDKPEL-------SFLNEFSQ-------------IFKGERDFSLAL 45
            ||....:||.|   |.:.||...:|       |..|...|             |.....||:...
Human    38 MHLIDYLLLLL---VGLLALSHGQLHVEHDGESCSNSSHQQILETGEGSPSLKIAPANADFAFRF 99

  Fly    46 MKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNK----------QQVL 100
            ...|....|..|:||||.|...|..:....:...:..::.:  .||:.|.:          |.:|
Human   100 YYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILE--GLGFNLTELSESDVHRGFQHLL 162

  Fly   101 VSYTLAQRQDEFRWRQSPMELSSANRIFVDRTIN------VSNKFNTLLYGATKELDFKNDPETG 159
              :||.........|.......|.|..|:.:.:|      .:..|:|..|          |....
Human   163 --HTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLFHTNFY----------DTVGT 215

  Fly   160 LKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINE---- 220
            ::.|||.:..:|..:|.|::|  |:....::||.|..|.|..|...|....|..|.|:::|
Human   216 IQLINDHVKKETRGKIVDLVS--ELKKDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTV 278

  Fly   221 ------REQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILP 279
                  ::||..:.:|         |..|...::::.|                |.|.::..|||
Human   279 RVPMMLQDQEHHWYLH---------DRYLPCSVLRMDY----------------KGDATVFFILP 318

  Fly   280 NSNKISLNRVISRLNADSVKKW----FERALPQKIELSLPKFQFEQRLELTPILSLMGVNTMFTR 340
            |..|  :..:...|..:.:.:|    .:|...:|:||.||||.......|..||..:|...:|::
Human   319 NQGK--MREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSK 381

  Fly   341 NATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVFLIY 405
            .|....:|... .|....:.|.|.:.|||.|:.|||||...:...|.|.:......|.||:.:|:
Human   382 WADLSGITKQQ-KLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILRFNRPFLVVIF 445

  Fly   406 DEKVDTILFAGVYSDP 421
            .....::||.|...||
Human   446 STSTQSVLFLGKVVDP 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	97/410 (24%)
SERPINA4	NP_001275961.1	alpha-1-antitrypsin_like	91..458	CDD:239011	97/410 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020