Protein Alignment Spn88Eb and SERPINA1

DIOPT Version :9

• Sequence 1: NP_650427.1
• Gene: Spn88Eb / 41829
• FlyBaseID: FBgn0038299
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 113/447 - (25%)
• Similarity: 199/447 - (44%)
• Gaps: 61/447 - (13%)

  Fly     3 TFSLVLLA----LLPVVTIA------ALDKPELSFLNE----FSQIFKGERDFSLALMKQIREIY 53
            ::.::|||    |:| |::|      |..|.:.|..::    |::|.....:|:.:|.:|:....
Human     6 SWGILLLAGLCCLVP-VSLAEDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQS 69

  Fly    54 PSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNKQQVLVSYTLAQRQDEFR----- 113
            .|.|:||||.|...|..:....:...|..|:.:.||..        |.....||..:.|:
Human    70 NSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFN--------LTEIPEAQIHEGFQELLRT 126

  Fly   114 --WRQSPMELSSANRIFVDRTINVSNKF----NTLLYGATKELDFKNDPETGLKEINDWIADKTH 172
              ...|.::|::.|.:|:...:.:.:||    ..|.:.....::| .|.|...|:|||::...|.
Human   127 LNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNF-GDTEEAKKQINDYVEKGTQ 190

  Fly   173 NQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAFKM 237
            .:|.|::  :|:...|:..|.|..:.||:|...|:|::|..:.|.:::.....|.||.:.|.|.:
Human   191 GKIVDLV--KELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNI 253

  Fly   238 TIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWF 302
            ...:.|.|.::.:.|                ..:.:.|..||:..|  |..:.:.|..|.:.|:.
Human   254 QHCKKLSSWVLLMKY----------------LGNATAIFFLPDEGK--LQHLENELTHDIITKFL 300

  Fly   303 ERALPQKIELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLTAD-PISLVIDDAQHLAKIK 366
            |....:...|.|||.......:|..:|..:|:..:|:..|....:|.: |:.|  ..|.|.|.:.
Human   301 ENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKL--SKAVHKAVLT 363

  Fly   367 VDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDPRQ 423
            :||.|:.||.|..|.....|..|: .||  |.|||||:.::...:.||.|...:|.|
Human   364 IDEKGTEAAGAMFLEAIPMSIPPE-VKF--NKPFVFLMIEQNTKSPLFMGKVVNPTQ 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	99/392 (25%)
SERPINA1	NP_000286.3	alpha-1-antitrypsin_like	55..412	CDD:239011	99/390 (25%)
		RCL	368..392		9/26 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010