DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and SERPIND1

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	409	Identity:	106/409 - (25%)
Similarity:	185/409 - (45%)	Gaps:	47/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QIFKGE----------RDFSLALMKQIR-EIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQ 86
            |:|.|:          ..|:..|.:.:: ::....|:|.:|.....|:.:.......:|..::..
Human   115 QLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHS 179

  Fly    87 ALNLGWALN---KQQVLVSYTLAQRQDE--FRWRQSPMELSSANRIFVDRTINVSNKFNTLL--- 143
            .|:....:|   |.::...:.|.::...  || |.....|.|.|.:::.:...:...|.|.:
Human   180 ILHFKDFVNASSKYEITTIHNLFRKLTHRLFR-RNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243

  Fly   144 YGATKELDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKV 208
            |.|..::...:|| ..:.:.|:.|...|...|:|.|  |.|.|.|.:::.|..|.||.|:::|.|
Human   244 YFAEAQIADFSDP-AFISKTNNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFKGSWVNKFPV 305

  Fly   209 EETALKPFFINEREQEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDIS 273
            |.|....|.:||||...|.||...|.|....|:.|...|::|.|                ...||
Human   306 EMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY----------------VGGIS 354

  Fly   274 MIIILPNSNKIS-LNRVISRLNADSVKKWFERALPQKIELSLPKFQFEQRLELTPILSLMGVNTM 337
            |:|::|  :|:| :..:.::|....|::|.:....:..|:.||||:.|:...|...|.|||:..:
Human   355 MLIVVP--HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRML 417

  Fly   338 FTRNATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVF 402
            |.:|.....::...|:  ||..:|...|.|:|.|:.|...|.:.....|.|   .:|..:.||:|
Human   418 FDKNGNMAGISDQRIA--IDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQ---VRFTVDRPFLF 477

  Fly   403 LIYDEKVDTILFAGVYSDP 421
            |||:.:...:||.|..::|
Human   478 LIYEHRTSCLLFMGRVANP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	103/400 (26%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	106/409 (26%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020