DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and Serpina3m

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001257911.1	Gene:	Serpina3m / 299276	RGDID:	735068	Length:	419	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	110/430 - (25%)
Similarity:	182/430 - (42%)	Gaps:	83/430 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LDKPELSFLNEFSQIFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTEREL 84
            ||...|..:|         .||:.:|.|.:....|..|:.|||.|...||.:....:...|..|:
  Rat    42 LDSLTLESIN---------TDFAFSLYKMLALKNPDKNVVFSPLSISAALAIVSLGAKGNTLEEI 97

  Fly    85 AQAL--NL------------GWALNKQQVLVSYTLAQRQDEFRWRQSPMELSSANRIFVDRTINV 135
            .:.|  ||            |..|.:        |:|..|:       :::.:.|.:|:|:.:.|
  Rat    98 LEVLRFNLTESYETDIHQGFGHLLQR--------LSQPGDQ-------VKIITGNALFIDKNLQV 147

  Fly   136 SNKFNTLLYGATKEL--------DFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVL 192
            ..:|..    .|:.|        ||: .|....|.|||::.::|..:|::::|.  :...|.:||
  Rat   148 LAEFQE----KTRALYQVEAFTADFQ-QPRVTEKLINDYVRNQTQGKIQELVSG--LKERTSMVL 205

  Fly   193 ANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMH----KTGAFKMTIDEGLQSQIIKLPYR 253
            .|....:|:|...|..:.|....|:::|:....|.||.    .|..|:   ||.|...:::|.|
  Rat   206 VNYLLFRGKWKVPFDPDYTFESEFYVDEKRSVKVSMMKIEELTTPYFR---DEELSCSVLELKY- 266

  Fly   254 TIYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQKI-ELSLPKF 317
                           ..:.|.:.|||:..:  :.:|.:.|..:::|||.:...|:|| ||.||:.
  Rat   267 ---------------TGNSSALFILPDKGR--MQQVEASLQPETLKKWKDSLRPRKIDELYLPRL 314

  Fly   318 QFEQRLELTPILSLMGVNTMFTRNATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAAT-ILL 381
            .......|..:|..:|:..:|::.|....:|... .|.:....|...:.|:|.|:.||||| ..|
  Rat   315 SISTDYSLEEVLPELGIRDVFSQQADLSRITGAK-DLSVSQVVHKVVLDVNETGTEAAAATGANL 378

  Fly   382 VSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDP 421
            |.||.|.|....|  |.||:..:......||||.....:|
  Rat   379 VPRSGRPPMIVWF--NRPFLIAVSHTHGQTILFMAKVINP 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	105/408 (26%)
Serpina3m	NP_001257911.1	SERPIN	56..416	CDD:214513	103/405 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100