DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and SERPINA11

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001073920.1	Gene:	SERPINA11 / 256394	HGNCID:	19193	Length:	422	Species:	Homo sapiens

Alignment Length:	400	Identity:	104/400 - (26%)
Similarity:	183/400 - (45%)	Gaps:	54/400 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNKQQVL---- 100
            :|:|.|.|::....| ||:||||.|....|.|....:...|...:.:.|........:..:
Human    56 NFALRLYKELAADAP-GNIFFSPVSISTTLALLSLGAQANTSALILEGLGFNLTETPEADIHQGF 119

  Fly   101 --VSYTLAQRQDEFRWRQSP-MELSSANRIFVDRTINVSNKF-NTL--LYGA-TKELDFKNDPET 158
              :.:|||        ..|| :||...|.:|:|:.:.....: :::  |||| ....:|.:...|
Human   120 RSLLHTLA--------LPSPKLELKVGNSLFLDKRLKPRQHYLDSIKELYGAFAFSANFTDSVTT 176

  Fly   159 GLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEET-ALKPFFINERE 222
            | ::|||::..:|:.|:.|.|  .|.:..|.:||||..:.|.:|...|...:| ..:.||::||.
Human   177 G-RQINDYLRRQTYGQVVDCL--PEFSQDTFMVLANYIFFKAKWKHPFSRYQTQKQESFFVDERT 238

  Fly   223 QEMVYMMHKTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLN 287
            ...|.|||:....:...|:.|...::::.||                .:...:::||:..|  :.
Human   239 SLQVPMMHQKEMHRFLYDQDLACTVLQIEYR----------------GNALALLVLPDPGK--MK 285

  Fly   288 RVISRLNADSVKKWFERALPQKIELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLTADPI 352
            :|.:.|...:::||.:..||..::|.||:|.......|..||..:|:..:....|.|..:|.. :
Human   286 QVEAALQPQTLRKWGQLLLPSLLDLHLPRFSISGTYNLEDILPQIGLTNILNLEADFSGVTGQ-L 349

  Fly   353 SLVIDDAQHLAKIKVDEVGSTAAAATILLVSRSSRQP------DPTKFNCNHPFVFLIYDEKVDT 411
            :..|....|.|.:.:.|.|:.|.||:.||    |:.|      || ..:.|.||:.|:::....:
Human   350 NKTISKVSHKAMVDMSEKGTEAGAASGLL----SQPPSLNTMSDP-HAHFNRPFLLLLWEVTTQS 409

  Fly   412 ILFAGVYSDP 421
            :||.|...:|
Human   410 LLFLGKVVNP 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	103/395 (26%)
SERPINA11	NP_001073920.1	alpha-1-antitrypsin_like	53..416	CDD:239011	103/395 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010