DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and Serpina3f

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001028507.2	Gene:	Serpina3f / 238393	MGIID:	2182838	Length:	445	Species:	Mus musculus

Alignment Length:	413	Identity:	100/413 - (24%)
Similarity:	175/413 - (42%)	Gaps:	78/413 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNKQQVLVSYT 104
            ||:.:|.|::....|..|:.|||||...||.|....:...|.:|:.:.|             .:.
Mouse    43 DFAFSLYKELVLKNPDENVVFSPFSICTALALLSLGAKSNTLKEILEGL-------------KFN 94

  Fly   105 LAQRQDE-----FRW-------RQSPMELSSANRIFVDRTINVSNKFN---TLLYGATK-ELDFK 153
            |.:..:.     ||:       ..:.:::|:.:.:|:::.:.:..:|.   ..||.|.. ..||:
Mouse    95 LTETPEPDIHQGFRYLLDLLSQPGNQVQISTGSALFIEKHLQILAEFKEKARALYQAEAFTADFQ 159

  Fly   154 NDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFI 218
             .|....|.|||::::.|..:|::::|  ::...|::||.|..|.||:|...|..::|....|::
Mouse   160 -QPLEATKLINDYVSNHTQGKIKELIS--DLDKRTLMVLVNYIYFKGKWEMPFDPDDTCKSEFYL 221

  Fly   219 NEREQEMVYMMH----KTGAFKMTIDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILP 279
            :|.....|.||.    .|..|:   ||.|...:::|.|                ..:.|.:.|||
Mouse   222 DENRSVKVPMMKINNLTTPYFR---DEELSCTVVELKY----------------TGNASAMFILP 267

  Fly   280 NSNKISLNRVISRLNADSVKKWFERALPQKI-ELSLPKFQFEQRLELTPILSLMGVNTMFTRNAT 343
            :..|  :.:|.:.|..::::.|.:...|:.| ||.||||.......|..||..:|:..:|:..|.
Mouse   268 DQGK--MQQVEASLQPETLRNWKDSLKPRLINELCLPKFSISTDYSLEHILPELGIRELFSTQAD 330

  Fly   344 FGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAAT----------ILLVSRSSRQPDPTKFNCNH 398
            ...:|... .|......|.|.:.|.|.|:.|||.|          ::.         ..|...:.
Mouse   331 LSAITGTK-DLRTSQVVHKAVLDVAETGTEAAAGTGYQNLQCCQGVIY---------SMKIYFDR 385

  Fly   399 PFVFLIYDEKVDTILFAGVYSDP 421
            ||:.:|.|......||....|:|
Mouse   386 PFLMIISDTNTHIALFMAKVSNP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	98/408 (24%)
Serpina3f	NP_001028507.2	alpha-1-antitrypsin_like	40..405	CDD:239011	98/408 (24%)
Serpina3f	NP_001028507.2	RCL	357..382		6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100