DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn88Eb and Serpine2

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_033281.1	Gene:	Serpine2 / 20720	MGIID:	101780	Length:	397	Species:	Mus musculus

Alignment Length:	429	Identity:	109/429 - (25%)
Similarity:	188/429 - (43%)	Gaps:	58/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLPVVTIAALDKPELSFLNEFSQIFKGE--RDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAY 73
            :|..||:       .|..::|:.:...|  .:..:.:..||.:..|..|:..||....:.|.:..
Mouse     9 ILTTVTL-------YSVHSQFNSLSLEELGSNTGIQVFNQIIKSRPHENVVVSPHGIASILGMLQ 66

  Fly    74 FSSSEQTERELAQAL-----NLGWALNK-QQVLVSYTLAQRQDEFRWRQSPMELSSANRIFVDRT 132
            ..:..:|:::|:..:     .:|..|.| .:.:||            :::...::.||.:|:...
Mouse    67 LGADGKTKKQLSTVMRYNVNGVGKVLKKINKAIVS------------KKNKDIVTVANAVFLRNG 119

  Fly   133 INVSNKF----NTLLYGATKELDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEIT-PHTMLVL 192
            ..:...|    ..:.....:.::|: ||.:..:.||.|:.::|...|.::||...|. ..|.|||
Mouse   120 FKMEVPFAVRNKDVFQCEVQNVNFQ-DPASASESINFWVKNETRGMIDNLLSPNLIDGALTRLVL 183

  Fly   193 ANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAFK---MTIDEGLQSQIIKLPYRT 254
            .||.|.||.|.|:|:.|.|..:.|...:.:...|.|:.:...|:   .....||....|:|||.
Mouse   184 VNAVYFKGLWKSRFQPESTKKRTFVAGDGKSYQVPMLAQLSVFRSGSTRTPNGLWYNFIELPYH- 247

  Fly   255 IYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQKIELSLPKFQF 319
                          ...|||:|.||..:...|:.:|..:...::..|....:|::::|.||||..
Mouse   248 --------------GESISMLIALPTESSTPLSAIIPHITTKTIDSWMNTMVPKRMQLVLPKFTA 298

  Fly   320 EQRLELTPILSLMGVNTMF-TRNATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAA-TILLV 382
            ..:.:|...|..:|:..|| ...|.|..:|... ||.:......|||:|.|.|:.|:|| |.:|:
Mouse   299 VAQTDLKEPLKALGITEMFEPSKANFTKITRSE-SLHVSHILQKAKIEVSEDGTKASAATTAILI 362

  Fly   383 SRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDP 421
            :|||    |..|..:.||:|.|.......|||.|..:.|
Mouse   363 ARSS----PPWFIVDRPFLFSIRHNPTGAILFLGQVNKP 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	103/398 (26%)
Serpine2	NP_033281.1	serpinE2_GDN	21..395	CDD:381039	104/406 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020