DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and Serpinf1

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_035470.3	Gene:	Serpinf1 / 20317	MGIID:	108080	Length:	417	Species:	Mus musculus

Alignment Length:	379	Identity:	96/379 - (25%)
Similarity:	166/379 - (43%)	Gaps:	48/379 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNK------QQVLVSYTLAQRQDEF 112
            |:||:..||.|...||......:..:||..:.:||......|.      :::|.|.|..::
Mouse    73 PTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEK---- 133

  Fly   113 RWRQSPMELSSANRIFVDRTINVSNKFNTLL---YGATKELDFKNDPETGLKEINDWIADKTHNQ 174
                   .|.||:||..:|.:.|.:.|...|   || |:......:|...|:|||:|:..:...:
Mouse   134 -------NLKSASRIVFERKLRVKSSFVAPLEKSYG-TRPRILTGNPRVDLQEINNWVQAQMKGK 190

  Fly   175 IRDMLSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGA-FKMT 238
            |  ..|:.|:.....::|...||.||||:::|...:|.|:.|.::|.....|.||....| .:..
Mouse   191 I--ARSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDEDRTVRVPMMSDPKAILRYG 253

  Fly   239 IDEGLQSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFE 303
            :|..|..:|.:||.                ...:|:|..||.:...:|..:...|.::.:.. .:
Mouse   254 LDSDLNCKIAQLPL----------------TGSMSIIFFLPLTVTQNLTMIEESLTSEFIHD-ID 301

  Fly   304 RALPQ-KIELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLTADPISLVIDDAQHLAKIKV 367
            |.|.. :..|::||.:.....|||..|..|.:.::| .:..|..:|..|:.|.  ..:|.|..:.
Mouse   302 RELKTIQAVLTVPKLKLSFEGELTKSLQDMKLQSLF-ESPDFSKITGKPVKLT--QVEHRAAFEW 363

  Fly   368 DEVGSTAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDP 421
            :|.|:.::.:..|   :..|...|..::.|.||:|::.|.....:||.|...||
Mouse   364 NEEGAGSSPSPGL---QPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRILDP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	94/374 (25%)
Serpinf1	NP_035470.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..41
Serpinf1	NP_035470.3	PEDF	39..414	CDD:239007	94/377 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100