Protein Alignment Spn88Eb and Serpina12

DIOPT Version :10

• Sequence 1: NP_650427.1
• Gene: Spn88Eb / 41829
• FlyBaseID: FBgn0038299
• Length: 426
• Species: Drosophila melanogaster
• Sequence 2: NP_620180.2
• Gene: Serpina12 / 191570
• RGDID: 708485
• Length: 414
• Species: Rattus norvegicus
• Alignment Length: 438
• Identity: 111/438 - (25%)
• Similarity: 206/438 - (47%)
• Gaps: 52/438 - (11%)

  Fly     5 SLVL---LALLPVVTIAAL----DKPELSFLNEFSQIFKGERD----------FSLALMKQIREI 52
            :|||   |.|..::|:..|    |.|:........|.::|::|          |...|::::...
  Rat     2 NLVLGLGLFLAGLLTVKGLLQDRDAPDTYESPVRVQEWRGKKDARELTRHNMEFGFKLLQRLASN 66

  Fly    53 YPSGNLFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWALNKQQVLVSYTLAQRQDEFRWRQS 117
            ...||:|.||.|...|..:....:...|..|:.:..|.....::...:..:.|.|:.:.   ...
  Rat    67 SRQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSDRDMHMGFHYLLQKLNR---ETQ 128

  Fly   118 PMELSSANRIFVDRTINVSNKFNTL---LYGATKELDFKNDPETGLKEINDWIADKTHNQIRDML 179
            .:::|..|.:|:|:.:....:|..|   ||.|...|....|.|...|.||.:|:.||||:|.:|:
  Rat   129 DVKMSIGNALFMDQRLRPQQRFLKLAKNLYDADMILTNFQDLENTQKNINKYISRKTHNRIENMV 193

  Fly   180 SSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAFKMTIDEGLQ 244
              :.|.|.|:::|.|..|.:|:|..:|..::|..:.|||.|.:...|.||.:.|.:.|..|..|.
  Rat   194 --KNIDPGTVMLLTNYIYFQGRWQYEFDPKQTKEEDFFIEEGKTVKVPMMFQRGMYDMAYDSQLS 256

  Fly   245 SQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQK 309
            ..|:::|||                .:|:...:||:|.|:.|  :...|.||...||......:.
  Rat   257 CTILEMPYR----------------RNITATFVLPDSGKLRL--LEQGLQADIFAKWKSLLSKRV 303

  Fly   310 IELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLT--ADPISLVIDDAQHLAKIKVDEVGS 372
            :::.:|:........:..:||.:|::.:|..:   ||||  :...||.:.:|.|.|:::::|.|:
  Rat   304 VDVWVPRLHISATYNMKKVLSRLGISKIFEEH---GDLTRISSHRSLKVGEAVHKAELRMNEKGT 365

  Fly   373 TAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILF-AGVYS 419
            ..||.:   .:::.....|.:...|.||:.:||:..:.:::| |.:|:
  Rat   366 EGAAGS---GAQTLPMETPRRMKLNAPFLMMIYENLMPSMIFLARIYN 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	serpin_crustaceans_chelicerates_insects	34..421	CDD:381059	101/402 (25%)
Serpina12	NP_620180.2	serpinA12_vaspin	40..411	CDD:381026	101/400 (25%)
		Reactive center loop. /evidence=ECO:0000250|UniProtKB:Q8IW75	364..382		3/20 (15%)