DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and SERPINA12

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001291390.1	Gene:	SERPINA12 / 145264	HGNCID:	18359	Length:	414	Species:	Homo sapiens

Alignment Length:	440	Identity:	115/440 - (26%)
Similarity:	204/440 - (46%)	Gaps:	62/440 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLALLPVVTIAALDKPELS-----FLNEF---------SQIFKGERDFSLALMKQIREIYPSGN 57
            :.||:|  :|:..|.||..|     .|:|.         .::.:...|....|:|::....|..|
Human     9 IFLAVL--LTVKGLLKPSFSPRNYKALSEVQGWKQRMAAKELARQNMDLGFKLLKKLAFYNPGRN 71

  Fly    58 LFFSPFSTYNALLLAYFSSSEQTERELAQALNLGWA----LNKQQVLVSYTLAQRQDEFRWRQSP 118
            :|.||.|...|..:....:.:.|..|:.|..|....    |::....:.:.|.|:..:
Human    72 IFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFHYIIHELTQKTQD------- 129

  Fly   119 MELSSANRIFVDRTINVSNKF-----NTLLYGATKELDFKNDPETGLKEINDWIADKTHNQIRDM 178
            ::||..|.:|:|:.:....||     |  .|.|...|....:.|...|:|||:|:.|||.:|.::
Human   130 LKLSIGNTLFIDQRLQPQRKFLEDAKN--FYSAETILTNFQNLEMAQKQINDFISQKTHGKINNL 192

  Fly   179 LSSEEITPHTMLVLANAAYMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAFKMTIDEGL 243
            :  |.|.|.|:::|||..:.:.:|..:|....|..:.||:.:.....|.||.::|.:::..|:.|
Human   193 I--ENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKL 255

  Fly   244 QSQIIKLPYRTIYKSKETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQ 308
            ...|:::||                :.:|:.|.|||:..|  |..:...|..|:..:|......:
Human   256 SCTILEIPY----------------QKNITAIFILPDEGK--LKHLEKGLQVDTFSRWKTLLSRR 302

  Fly   309 KIELSLPKFQFEQRLELTPILSLMGVNTMFTRNATFGDLT--ADPISLVIDDAQHLAKIKVDEVG 371
            .:::|:|:.......:|...||.:||:.:|..:   ||||  |...||.:.:|.|.|::|:||.|
Human   303 VVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEEH---GDLTKIAPHRSLKVGEAVHKAELKMDERG 364

  Fly   372 STAAAATILLVSRSSRQPDPTKFNCNHPFVFLIYDEKVDTILFAGVYSDP 421
            :..||.|   .:::.....|.....:.|::.|||.||:.::||.|...:|
Human   365 TEGAAGT---GAQTLPMETPLVVKIDKPYLLLIYSEKIPSVLFLGKIVNP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	104/391 (27%)
SERPINA12	NP_001291390.1	serpinA12_vaspin	40..411	CDD:381026	104/405 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010