DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn88Eb and serpine1

DIOPT Version :9

Sequence 1:	NP_650427.1	Gene:	Spn88Eb / 41829	FlyBaseID:	FBgn0038299	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001108031.1	Gene:	serpine1 / 100136840	ZFINID:	ZDB-GENE-070912-60	Length:	384	Species:	Danio rerio

Alignment Length:	420	Identity:	106/420 - (25%)
Similarity:	186/420 - (44%)	Gaps:	54/420 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPVVTIAALDKPELSFLNEFSQIFKGERDFSLALMKQIREIYPSGNLFFSPFSTYNALLLAYFSS 76
            |.|:.|.||....|..|.:..|     .||.|.:..:..:..|..||..||:...:.|.:|...:
Zfish     4 LSVLLIFALCASSLCNLIQDKQ-----TDFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGA 63

  Fly    77 SEQTERELAQALNLGWALNKQQVLVSYTLAQRQDEFRWRQSPMELSS------ANRIFVDRTINV 135
            ...|.:.||.  .:|::|.::.:.....|.||           :|:|      |:.:.|||.|.:
Zfish    64 YGATLKLLAS--KMGYSLQERGMPKLQRLLQR-----------DLASEDGVEVASGVMVDRKIIL 115

  Fly   136 SNKFNTLLYGATK----ELDFKNDPETGLKEINDWIADKTHNQIRDMLSSEEITPHTMLVLANAA 196
            ...|...|..|.:    ::|| :.||...:.||.|.:|.|...|.:.|.|..::..|.||..||.
Zfish   116 EKVFRRSLSKAFQSVPHQIDF-SQPEMARQVINSWTSDHTDGMISEFLPSGVLSELTRLVFLNAL 179

  Fly   197 YMKGQWLSQFKVEETALKPFFINEREQEMVYMMHKTGAF---KMTIDEGLQSQIIKLPYRTIYKS 258
            :..|.|.:.|....|..:.|.........|.||..|..|   :....:|:...:|::||
Zfish   180 HFHGVWKTPFDPRNTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPY------ 238

  Fly   259 KETHISTPESKSDISMIIILPNSNKISLNRVISRLNADSVKKWFERALPQKIELSLPKFQFEQRL 323
                    |.:| |||:::.|....:.|:.:...|::..:.:|.:.......:||:|:|..:..:
Zfish   239 --------EGES-ISMLLVTPFEKDVPLSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEI 294

  Fly   324 ELTPILSLMGVNTMFTRN-ATFGDLTADPISLVIDDAQHLAKIKVDEVGSTAAAATILLV-SRSS 386
            :|...||.||:..:|::: |.|..:|.:. .|.:.......|::|:|.|:..::||..:: ||.:
Zfish   295 DLKSTLSRMGLGDIFSQSRADFSRITTEE-PLCVSKVLQRVKLEVNEEGTKGSSATAAVIYSRMA 358

  Fly   387 RQPDPTKFNCNHPFVFLIYDEKVDTILFAG 416
            .:    :...:.||.|||..:....:||:|
Zfish   359 VE----EITLDRPFFFLIQHKPTGALLFSG 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn88Eb	NP_650427.1	SERPIN	37..418	CDD:238101	98/395 (25%)
serpine1	NP_001108031.1	SERPIN	26..384	CDD:294093	97/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020