DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6752 and Rnf123

DIOPT Version :9

Sequence 1:	NP_001247116.1	Gene:	CG6752 / 41826	FlyBaseID:	FBgn0038296	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001298081.1	Gene:	Rnf123 / 84585	MGIID:	2148796	Length:	1320	Species:	Mus musculus

Alignment Length:	1359	Identity:	408/1359 - (30%)
Similarity:	644/1359 - (47%)	Gaps:	230/1359 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 DKFQQIQTDSNEEIRRLYMETESRIGPDLTIFD--VDYTTTVRVSSDRLALRSQGSFNTVRANCC 128
            |:..|:.::.||.    ..:.|.|:||...:.|  ..:...:.|..|.|.:....:|.|:|:..|
Mouse    69 DQLLQVDSEDNES----QGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTC 129

  Fly   129 VYGGRWMYEIHLHTKGVMQIGWASNSCQFNENSGVGDTKSSYGYDGSKQQIWHISTKKYGDKWQI 193
            ||.|:|:||:.:.::|:|||||.:.:|:||:..|||||.:||.|||::.:.|:::|..||..|..
Mouse   130 VYKGKWVYEVLISSQGLMQIGWCTINCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAA 194

  Fly   194 GDVIGVTIDVDKEVIEYYRNGRSMGVAFNKLEKGPGISFFAAISLGYTQGIEANFGNRPFMYPVS 258
            ||::...||:|...:.:..||.|:|.||..|.:|.|:::|.||||.:.:.:..|||:||..|||:
Mouse   195 GDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVA 259

  Fly   259 GFQPLMARPILKLQRANLLMNYLVNLAGIFSKY------NAQSGMAPTNGADARVSTKKTVYCIF 317
            ||:||...|...|.||..|:       |.|...      ..:..:..|..::.::..:.||....
Mouse   260 GFRPLQDPPFADLVRAQRLL-------GCFQAVLSVELDPVEGRLVETESSEWQLQGQPTVLLTL 317

  Fly   318 ATLLIEKFTNEIFDPYIIEDVLLRKISSMTNLASEKENSYSVLHGLLSLFWNYMEGDEIKFVLRK 382
            |. :...|...:...|::|.||:..:..:....: .|.:.||:|.:|.|.|.:||..|::..|::
Mouse   318 AH-IFHHFAPLLRKVYLVEAVLMSFLLGVVEKGT-PEQAQSVVHQILDLLWLFMEDYEVQDCLKQ 380

  Fly   383 LVNALLG--TFTHTIQGLDYEKHRQALGMLHCLCLHEQTRKYLLEGKLFKKHCLAFFLYI-HPL- 443
            |:.:||.  .|:..:..|..:.|...|.|  .:..||::||:||...||.......|.|| .||
Mouse   381 LMMSLLRLYRFSPIVPDLGLQIHYLRLTM--SILRHEKSRKFLLSNVLFDMLRSVVFFYIKSPLR 443

  Fly   444 -EFYIMEELLPDSMAW-----TEGIDGPKEK------------YLNVVEKVRKVTEPLYTAQKDL 490
             |...::||:|.:. |     .|..||.:.:            |....::::|..|.:...|..:
Mouse   444 VEEAGLKELIPTTW-WPHRSSRESRDGKEAREETTEERQRRRAYERGCQRLKKRIEVVEELQVQI 507

  Fly   491 LCTLMINSDGSRESPSSRSIFLSKLRRYVIDLSMEQRPFHAFFFMQSSIQHPLDAPV------AL 549
            |..|:.|.| .....:||.|||:|.|:                |:|.:.....:.||      .:
Mouse   508 LKLLLDNKD-DNGGEASRYIFLTKFRK----------------FLQENASGRGNTPVLCPPEYMV 555

  Fly   550 AFASILIDQTRSMFKDEMPTKN--------VEVNSDYFIDGTFDYMHFDRVGGVLSHLRKVHRGD 606
            .|...|:...| .:.||....|        ..:....|.:|..||....|:||:||||||..:.|
Mouse   556 CFLHRLVSALR-FYWDEYKASNPRASFSEEAYIPPQIFYNGKVDYFDLQRLGGLLSHLRKTLKDD 619

  Fly   607 IDARLG--------SARTQ--------------QIYEDDRQNLRVNEVDTTLYLLGENINNVPVV 649
            :.::..        .|.|.              |::::.::.::...:...|.|......:.|.:
Mouse   620 LASKANIVIDPLELQAATMDDLDEDEEPAPSAAQVWQEGQRPMQALAIGGALPLPRPGWLSSPTL 684

  Fly   650 GH------TQGANNTTYTHFLNT-------------RPNSSTDSSPGNADM-------------- 681
            |.      |...:..|....|:|             |.....:.|..|..:
Mouse   685 GRANRFLSTAAVSLMTPRRLLSTMEKVKVRSLNVEQRTREDIEGSHWNEGLLLGRPPEEPEQPLT 749

  Fly   682 EASLCELLDLCIIFYYSAGHKYIVKIATVRDEIAALNEVLKETKFYREDIERKLGALEQHANVCM 746
            |.||.|:||..::.|..:.|:.:.|:..|.|::......|::|    ||..|:          |
Mouse   750 ENSLLEVLDGTVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDT----EDKLRR----------C- 799

  Fly   747 NENHQHVMGELRSKFSQRQNVFATRSIALARKQVWLRGVALNNHRRSLLIWLLERMLRTLTTASN 811
            .:..:.::.||    ::.|.||:.:...|:|:..|:.....:..:...:.|||...|||:.....
Mouse   800 PKRRKDILAEL----TKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGDR 860

  Fly   812 TGSLFSFVPEVYVNTLPILLDAVMDFSHHDLKAQF-------EASDAECSVNAAAEFLGIHSADP 869
            |||||:|:||.|::.      |:..:|  .||..|       |....|.::...|..|..|.|||
Mouse   861 TGSLFAFMPEFYLSV------AINSYS--ALKNYFGPVHSMEELPGYEETLTRLAAILAKHFADP 917

  Fly   870 RIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVRALLRPYENRAWGQSNWLLLRFWMG 934
            |||....:|||:|||.:..|:...:||:||..:..:.::||.||.|||.|.|.|:||:|:|.|.|
Mouse   918 RIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWRG 982

  Fly   935 EGYAYKDSRQPSVW----QGGSLPLHQGLCRSRSRNETHTGLLHNVAPANPSKHFQRLIGAKLLE 995
            .|:.|:.:|.|.:.    :..:||..|..|                    ||...|:.:...|.:
Mouse   983 CGFGYRYTRLPHLLKTKPEDANLPSLQKPC--------------------PSTLLQQHMADLLRQ 1027

  Fly   996 DEPFATAFLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLMRCLE 1060
            ....|.:||||||:||||||||||.::||||..|:|.|....:.:|||:|:.||:|:|||:|.||
Mouse  1028 GSDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRVLE 1092

  Fly  1061 MVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYPIVTA 1125
            |.||..|||..|.|||.|::||.|:.||::|||:|||.....|..||.:....|.:|.||||:.|
Mouse  1093 MTITLVPEIFLDWSRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPILVA 1157

  Fly  1126 ALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFDPS 1190
            ..|||:.|:.....|:     ..:.:...|.||.||..::.:.||:
Mouse  1158 VTGILVRLLVHGPTSE-----TEQATSVLLADPCFQLRSICYLLGQ------------------- 1198

  Fly  1191 SRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSD 1255
              |  :||.....:|.|:..          :|:|..:..::|:||:..|.:::..|.......:.
Mouse  1199 --P--EPLAPGTTLPAPDRK----------RFSLQSYTDYISAEELAQVEQMLAHLTAASAQAAA 1249

  Fly  1256 ITLP-SEDSLCPICCAKPITAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQTIETLD 1313
            .:|| :|:.|||||.|.||:|||.||.|:||..||.||:||:|.||:||.||.::|..|
Mouse  1250 ASLPTNEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKATIVSVEDWD 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6752	NP_001247116.1	SPRY_RNF123	122..249	CDD:293940	53/126 (42%)
CG6752	NP_001247116.1	zf-C3HC4_3	1261..1309	CDD:290631	30/47 (64%)
Rnf123	NP_001298081.1	SPRY_RNF123	123..250	CDD:293940	53/126 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..483		3/22 (14%)
		RING-HC_RNF123	1258..1298	CDD:319455	25/39 (64%)
		RING-HC finger (C3HC4-type)	1260..1297	CDD:319455	24/36 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837615
Domainoid	1	1.000	350	1.000	Domainoid score	I1019
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11112
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1059
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60087
OrthoDB	1	1.010	-	-		D133044at33208
OrthoFinder	1	1.000	-	-		FOG0006357
OrthoInspector	1	1.000	-	-		oto94037
orthoMCL	1	0.900	-	-		OOG6_107536
Panther	1	1.100	-	-	LDO	PTHR13363
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770