DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6752 and RKP

DIOPT Version :9

Sequence 1:	NP_001247116.1	Gene:	CG6752 / 41826	FlyBaseID:	FBgn0038296	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001189573.1	Gene:	RKP / 816737	AraportID:	AT2G22010	Length:	1283	Species:	Arabidopsis thaliana

Alignment Length:	1379	Identity:	319/1379 - (23%)
Similarity:	548/1379 - (39%)	Gaps:	319/1379 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 IVRTWLDDKFQQIQTDSNEEI--RRLYMETESRIGPDLT-IFDVDYTTTVRVSSDRLALRSQGSF 120
            ::|..:.::|.::..|.:..:  |.........:||.:. :.:......:|:....|.|.|...|
plant    71 LIRAVIKNQFSKLHGDLDVSVSQREGISVVHHGVGPPIVGLEEFSICGDIRIVKPPLVLESLALF 135

  Fly   121 NTVRANCCVYGGRWMYEIHLHTKGVMQIGWASNSCQFNENSGVGDTKSSYGYDGSKQQIWHISTK 185
            ::.|||.|::.|:||||:.|.|.|:.|:|||:.:|.|.:..||||...||.:||.:...|:...:
plant   136 SSARANACIWKGKWMYEVALETSGIQQLGWATLACPFTDQKGVGDADDSYAFDGRRVSKWNKEAE 200

  Fly   186 KYGDKWQIGDVIGVTIDVDKEVIEYYRNGRSMGVAFNKLEK-GPGISFFAAISLGYTQGIEANFG 249
            .||..|..|||||..||::.:.|.:||||.|:|.||..:.| |||..::.||||...:..|.|||
plant   201 PYGQSWVAGDVIGCCIDLNCDEIYFYRNGVSLGAAFTGIRKLGPGFGYYPAISLSQGERCELNFG 265

  Fly   250 NRPFMYPVSGFQPLMARPILKLQRANLLMNYLVNLAGIFSKY--NAQSGMAPTNGADARVSTKKT 312
            ..||.|||.||||        ||.|....::...|...||:.  .....:|.|.....|.::.:.
plant   266 AYPFKYPVDGFQP--------LQEAPTRFSFATELLRCFSRLLDRPDRSLADTLSRLRRFASVEE 322

  Fly   313 VYCIFATLLIEKFTNEIFDPYIIE-DVLLRKISS--------MTNLASEKENSYSVLHGLLSLFW 368
            ::|..::.:.::|.      ||:| |.||.:...        :....::..:..|.|..:|.:|
plant   323 LFCPVSSAICDEFF------YILEQDPLLAEYLGRGAFLSFLLETFRTQAPHDSSSLDKVLDVF- 380

  Fly   369 NYMEGDEIKFVLRKLVNAL-LGTFTHTIQGLDYEKHRQALGMLHCLCLHEQTRKYL-LEGKLFKK 431
              :|..:...:...:|||| .|..|.|              ::...|.:.....|| |...|||:
plant   381 --LEFPQSHLIFEHVVNALACGCKTAT--------------LILTECPYSGPYPYLALACHLFKR 429

  Fly   432 HCLAF--------------FLYIHPLEFYIMEELLP--------------DSMAWT-----EGID 463
            ..|..              ||.......:.::.|:|              .||.:|     |.|:
plant   430 EELMVQWWRSLHFEFLFEGFLSCRSSNKHDLQHLMPVVWWPGSSEDISYESSMGFTISALSEAIN 494

  Fly   464 GPKEKYLN----VVEKVRKVTEPLY--TAQKDLLCTLMINSDGSRE--SPS--SRSIFLSKLRRY 518
            ..:||..|    |::.:..|:.|..  :|.:..|..|::.:.|:..  :||  :|:..|..|...
plant   495 KIEEKQRNLCLLVIQFIPPVSPPQLPGSAFRGFLQNLLLKNRGADRTLAPSGVTRNSVLVSLFSV 559

  Fly   519 VIDLSMEQRPFHAFFFMQSS--IQHPLDAPVALAFASILIDQTRSMFKDEMPTKNVEVNSDYFID 581
            ::....|     .|..::||  :.|.:         ..|....:..|...:..||....:|
plant   560 ILHFLSE-----GFAMLKSSEAVHHNV---------GFLHRGGQQKFPLSLFLKNDPHRAD---- 606

  Fly   582 GTFDYMHFDRVGGVLSHLRKVHRGDIDARLGSARTQQIYEDDRQNLRVN-------------EVD 633
                   ..|:||:.||:.|.:..| |......|.::...||.|| ||.             :.|
plant   607 -------ITRLGGLFSHISKSYPTD-DQEEEIMRWEEGCMDDEQN-RVTHATEQKPCCCLAYDTD 662

  Fly   634 TTLYL--LGEN--------INNVPVVGHTQGANNT--TYTHFLNTRPNSSTDSSPG--------- 677
            .|..|  .|:|        .:::|.......|..:  :::..::.:|::|..|.|.
plant   663 LTKSLKDRGKNTAQSSRGRCSSIPERSSHVAAECSAGSFSEEIDDKPSTSNQSDPDFGYRPVRFM 727

  Fly   678 -NADMEASLC-------ELLDLCIIFYYSAGHKYIVKIATVRDEIAALNEVLKETKFYREDIERK 734
             .|..|:.:.       ||||..::.|:.|               .|.|  .|:..:|.....:.
plant   728 RTALQESRISSAILSEEELLDALLLLYHIA---------------VAPN--FKQASYYMSHQSQS 775

  Fly   735 LGALEQHANVCMNENHQHVMGELRSKFSQRQNVFATRSIALARKQVWLRGVALNNHRR----SLL 795
            :..||:    ...:..:....:...:..:.:|.:....:...|...|.|....:..::    :|.
plant   776 ISLLEE----TDKQIRERASCDQIKRLKEARNNYKEDVMDCVRHSAWFRISLFSRWKQRGMYALC 836

  Fly   796 IWLLERMLRTLTTASNTGSLFSFVPEVYVNTLPILLDAVMDFSHHDLKAQ--FEASDA--ECSVN 856
            :|:::.:|    ..|...|:|.::||.|       |::::|..|...|:.  |..|..  :..::
plant   837 MWVVQLLL----VLSKMDSVFVYIPEFY-------LESLVDCFHVLRKSDPPFVPSTTFIKQGLS 890

  Fly   857 AAAEFLGIHSADPRIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVRALLRPYENRAW 921
            :...|:..|..|.||.....||.|||::..|..:|..:.|.| .::.:...:..|||..::||:|
plant   891 SFITFVVTHFNDSRISNTDLKDLLLQSISVLVQYKEYLEAFE-NNEAATRHMPAALLAAFDNRSW 954

  Fly   922 GQSNWLLLRFWMGEGYAYKDSRQPSVWQGGSLPLHQGLCRSRSRNETHTGLLHNVAPANPSKHFQ 986
            .....:.||...|.|::                                 .|.|...:..|..||
plant   955 IPVTNIFLRLCKGSGFS---------------------------------SLKNGESSFSSTVFQ 986

  Fly   987 RLIGAKLLEDEPFATAFLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFEL 1051
            .|:....:.|....:.|||.:.:.|:|..:||.:.::|:|...|..|   |:.::   |.:.|||
plant   987 ALLRDACINDGELLSTFLNRLFNTLSWTITEFSVSVREMQEKYQVME---FQQRK---CCVIFEL 1045

  Fly  1052 TVSLMRCLEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNA 1116
            :.:|.|.||......|:...    ..:|..|.|:.:||..:|:.:|       ..||....||:.
plant  1046 SSNLARVLEFCTYAMPQAFL----AGTDTNLRRLTELILFILNHMT-------SAVDDEFFDLSV 1099

  Fly  1117 ------------VTHYPIVTAALGILLALMQEEMESDLRPQIVTRVSRAF--LTDPSFQFATLEF 1167
                        |:...::...:||:|.|:  |...|.:|:....|...|  :..|...:...::
plant  1100 RSLRRQGQPSEKVSRGILLAPLVGIILNLL--EASEDSKPKQQHDVIGLFASMDCPDTVYYGFQY 1162

  Fly  1168 ALGEIRTPLLEQKNIPRGNFDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFA-LNDFPSHV 1231
                    |||.      |:|..       ::.|              |..:.|.. |.:|.||:
plant  1163 --------LLEY------NWDGC-------VSGD--------------DAYVKKLGQLENFLSHL 1192

  Fly  1232 ----SSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPITAVFTPCKHQSCSDCIMQH 1292
                ||:|.:.          |:...:..|...||:.|.||.|....|:..||.|:||..||.:|
plant  1193 INRASSQEPER----------KEESFNKDTTDIEDNTCCICYAGEANAMIAPCSHRSCYGCITRH 1247

  Fly  1293 MMNSKVCFYCKTTI 1306
            ::|.:.||:|..|:
plant  1248 LLNCQRCFFCNATV 1261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6752	NP_001247116.1	SPRY_RNF123	122..249	CDD:293940	56/127 (44%)
CG6752	NP_001247116.1	zf-C3HC4_3	1261..1309	CDD:290631	20/46 (43%)
RKP	NP_001189573.1	SPRY_RNF123	137..265	CDD:293940	56/127 (44%)
		Ufd2P_core	<852..>949	CDD:287392	27/104 (26%)
		zf-C3HC4_3	1216..1264	CDD:290631	20/46 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	119	1.000	Domainoid score	I1917
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11112
Inparanoid	1	1.050	271	1.000	Inparanoid score	I918
OMA	1	1.010	-	-		QHG60087
OrthoDB	1	1.010	-	-		D54386at2759
OrthoFinder	1	1.000	-	-		FOG0006357
OrthoInspector	1	1.000	-	-		oto4104
orthoMCL	1	0.900	-	-		OOG6_107536
Panther	1	1.100	-	-	LDO	PTHR13363
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5310
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840