DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6752 and Rspry1

DIOPT Version :9

Sequence 1:	NP_001247116.1	Gene:	CG6752 / 41826	FlyBaseID:	FBgn0038296	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_001346022.1	Gene:	Rspry1 / 67610	MGIID:	1914860	Length:	576	Species:	Mus musculus

Alignment Length:	234	Identity:	71/234 - (30%)
Similarity:	113/234 - (48%)	Gaps:	31/234 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LADLSVTKQMLIVRTWLDDK---FQQIQTDSNEEIRRLYMETESRIGPDLTIFDVDYTTT----- 104
            :::.|::.:::.:..|.||.   .:|:...:...:..|:::.    |..||...||....
Mouse   263 ISESSISDRLVTLELWADDPDYLKRQVGFCAQWSLDNLFLKE----GRQLTYEKVDLNNIRAMLN 323

  Fly   105 -------VRVSSDRLALR-SQGSFNTVRANCCVYGGRWMYEIHLHTKGVMQIGWASNSCQF--NE 159
                   :::|...|..| ...||.:||...||..|.|.||:.:.|.||||||||:...:|  :|
Mouse   324 SNDVSEYLKISPHGLEARCDASSFESVRCTFCVDTGVWYYEVTVVTSGVMQIGWATRDSKFLNHE 388

  Fly   160 NSGVGDTKSSYGYDGSKQQIWHISTKK--YGDKWQIGDVIGVTIDVDKEVIEYYRNGRSM---GV 219
            ..|:||.:.|..|||.:|.||:.:..|  ....|:.||.:|..:|::::.:.::.||..:   ..
Mouse   389 GYGIGDDEYSCAYDGCRQLIWYNARSKPHVHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQ 453

  Fly   220 AFNKLEKGPGISFFAAISLGYTQGIEANFGNRPFMYPVS 258
            .|:....|    ||||.|....|..|.|||.|||.||.|
Mouse   454 VFSSTVSG----FFAAASFMSYQQCEFNFGARPFKYPPS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6752	NP_001247116.1	SPRY_RNF123	122..249	CDD:293940	47/133 (35%)
CG6752	NP_001247116.1	zf-C3HC4_3	1261..1309	CDD:290631
Rspry1	NP_001346022.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..99
		SPRY_RING	359..479	CDD:293941	43/123 (35%)
		RING-HC_RSPRY1	525..565	CDD:319480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5105
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.720