DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6752 and RNF123

DIOPT Version :9

Sequence 1:	NP_001247116.1	Gene:	CG6752 / 41826	FlyBaseID:	FBgn0038296	Length:	1332	Species:	Drosophila melanogaster
Sequence 2:	NP_071347.2	Gene:	RNF123 / 63891	HGNCID:	21148	Length:	1314	Species:	Homo sapiens

Alignment Length:	1358	Identity:	417/1358 - (30%)
Similarity:	648/1358 - (47%)	Gaps:	244/1358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QQIQTDSNEEIRRLYMETESRIGPDLTIFD--VDYTTTVRVSSDRLALRSQGSFNTVRANCCVYG 131
            |.:|.|:.||  ....:.|.|:||...:.|  ..:...:.|..|.|.:....:|.|:|:..|||.
Human    70 QLLQVDNEEE--ESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYK 132

  Fly   132 GRWMYEIHLHTKGVMQIGWASNSCQFNENSGVGDTKSSYGYDGSKQQIWHISTKKYGDKWQIGDV 196
            |:|:||:.:.::|:|||||.:.||:||:..|||||.:||.|||::.:.|:::|..||..|..||:
Human   133 GKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDI 197

  Fly   197 IGVTIDVDKEVIEYYRNGRSMGVAFNKLEKGPGISFFAAISLGYTQGIEANFGNRPFMYPVSGFQ 261
            :...||:|...:.:..||.|:|.||..|.:|.|:::|.||||.:.:.:..|||:||..|||:|::
Human   198 VSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYR 262

  Fly   262 PLMARPILKLQRANLLMNYL-----VNLAGIFSK-YNAQSGMAPTNGADARVSTKKTVYCIFATL 320
            ||...|...|.||..|:...     |.|..:..: .:.:|......|....:.|...::..||.|
Human   263 PLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPL 327

  Fly   321 LIEKFTNEIFDPYIIEDVLLRKISSMTNLASEKENSYSVLHGLLSLFWNYMEGDEIKFVLRKLVN 385
            |.:        .|::|.||:..:..:....:..: :.||:|.:|.|.|.:||..|::..|::|:.
Human   328 LRK--------VYLVEAVLMSFLLGIVEKGTPTQ-AQSVVHQVLDLLWLFMEDYEVQDCLKQLMM 383

  Fly   386 ALLG--TFTHTIQGLDYEKH--RQALGMLHCLCLHEQTRKYLLEGKLFKKHCLAFFLYI-HPL-- 443
            :||.  .|:..:..|..:.|  |..:.:|.    ||::||:||...||.......|.|| .||
Human   384 SLLRLYRFSPIVPDLGLQIHYLRLTIAILR----HEKSRKFLLSNVLFDVLRSVVFFYIKSPLRV 444

  Fly   444 EFYIMEELLPDSMAW-----TEGIDGPKEK------------YLNVVEKVRKVTEPLYTAQKDLL 491
            |...::||:|.:. |     .||.:..:.|            |....:::||..|.:...|..:|
Human   445 EEAGLQELIPTTW-WPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQIL 508

  Fly   492 CTLMINSDGSRESPSSRSIFLSKLRRYVIDLSMEQRPFHAFFFMQSSIQHPLDAPV------ALA 550
            ..|:.|.| .....:||.|||:|.|:                |:|.:.....:.|:      .:.
Human   509 KLLLDNKD-DNGGEASRYIFLTKFRK----------------FLQENASGRGNMPMLCPPEYMVC 556

  Fly   551 FASILIDQTRSMFKDEMPTKN--------VEVNSDYFIDGTFDYMHFDRVGGVLSHLRKVHRGDI 607
            |...||...| .:.||....|        ..:....|.:|..||....|:||:||||||..:.|:
Human   557 FLHRLISALR-YYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDL 620

  Fly   608 DAR---------LGSARTQQIYEDD-------RQNLRVNEVDTTLYLLGENINNVPVVGHTQGAN 656
            .::         |.|.....:.||:       ::.::...|...|.|......:.|.:|.   ||
Human   621 ASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGR---AN 682

  Fly   657 NTTYTHFLNT---------RPNSSTD--------------------------------SSPGNAD 680
                 .||:|         ||.|:::                                ..|....
Human   683 -----RFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPL 742

  Fly   681 MEASLCELLDLCIIFYYSAGHKYIVKIATVRDEIAALNEVLKETKFYREDIERKLGALEQHANVC 745
            .|.||.|:||..::.|..:.|:.:.|:..|.|::......|::|    ||..|:          |
Human   743 TENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDT----EDKLRR----------C 793

  Fly   746 MNENHQHVMGELRSKFSQRQNVFATRSIALARKQVWLRGVALNNHRRSLLIWLLERMLRTLTTAS 810
             .:..:.::.||    ::.|.||:.:...|:|:..|:.....:..:...:.|||...|||:....
Human   794 -PKRRKDILAEL----TKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGD 853

  Fly   811 NTGSLFSFVPEVYVNTLPILLDAVMDFSHHDLKAQF-------EASDAECSVNAAAEFLGIHSAD 868
            .|||||:|:||.|::.      |:..:|  .||..|       |....|.::...|..|..|.||
Human   854 RTGSLFAFMPEFYLSV------AINSYS--ALKNYFGPVHSMEELPGYEETLTRLAAILAKHFAD 910

  Fly   869 PRIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVRALLRPYENRAWGQSNWLLLRFWM 933
            .|||....:|||:|||.:..|:...:||:||..:..:.::||.||.|||.|.|.|:||:|:|.|.
Human   911 ARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWR 975

  Fly   934 GEGYAYKDSRQPSV----WQGGSLPLHQGLCRSRSRNETHTGLLHNVAPANPSKHFQRLIGAKLL 994
            |.|:.|:.:|.|.:    .:..:||..|..|                    ||...|:.: |.||
Human   976 GCGFGYRYTRLPHLLKTKLEDANLPSLQKPC--------------------PSTLLQQHM-ADLL 1019

  Fly   995 EDEP-FATAFLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLMRC 1058
            :..| .|.:||||||:||||||||||.::||||..|:|.|....:.:|||:|:.||:|:|||:|.
Human  1020 QQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRV 1084

  Fly  1059 LEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYPIV 1123
            |||.||..|||..|.:||.|::||.|:.||::|||:|||.....|..||.:....|.:|.||||:
Human  1085 LEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPIL 1149

  Fly  1124 TAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFD 1188
            .|..|||:.|:.....|: |.|    .:...|.||.||..::.:.||:
Human  1150 VAVTGILVQLLVRGPASE-REQ----ATSVLLADPCFQLRSICYLLGQ----------------- 1192

  Fly  1189 PSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLL 1253
                |  :|......:|.|:..          :|:|..:..::|::|:..|.:::..|.......
Human  1193 ----P--EPPAPGTALPAPDRK----------RFSLQSYADYISADELAQVEQMLAHLTSASAQA 1241

  Fly  1254 SDITLP-SEDSLCPICCAKPITAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQTIE 1310
            :..:|| ||:.|||||.|.||:|||.||.|:||..||.||:||:|.||:|||||.::|
Human  1242 AAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVE 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6752	NP_001247116.1	SPRY_RNF123	122..249	CDD:293940	54/126 (43%)
CG6752	NP_001247116.1	zf-C3HC4_3	1261..1309	CDD:290631	31/47 (66%)
RNF123	NP_071347.2	SPRY_RNF123	123..250	CDD:293940	54/126 (43%)
RNF123	NP_071347.2	zf-C3HC4_3	1250..1298	CDD:290631	31/47 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147536
Domainoid	1	1.000	332	1.000	Domainoid score	I1137
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11112
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1115
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60087
OrthoDB	1	1.010	-	-		D133044at33208
OrthoFinder	1	1.000	-	-		FOG0006357
OrthoInspector	1	1.000	-	-		oto90453
orthoMCL	1	0.900	-	-		OOG6_107536
Panther	1	1.100	-	-	LDO	PTHR13363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5412
SonicParanoid	1	1.000	-	-		X5310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800