Protein Alignment Kpc1 and RNF123

DIOPT Version :10

• Sequence 1: NP_650425.1
• Gene: Kpc1 / 41826
• FlyBaseID: FBgn0038296
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: NP_071347.2
• Gene: RNF123 / 63891
• HGNCID: 21148
• Length: 1314
• Species: Homo sapiens
• Alignment Length: 1358
• Identity: 417/1358 - (30%)
• Similarity: 648/1358 - (47%)
• Gaps: 244/1358 - (17%)

  Fly    69 QQIQTDSNEEIRRLYMETESRIGPDLTIFD--VDYTTTVRVSSDRLALRSQGSFNTVRANCCVYG 131
            |.:|.|:.||  ....:.|.|:||...:.|  ..:...:.|..|.|.:....:|.|:|:..|||.
Human    70 QLLQVDNEEE--ESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYK 132

  Fly   132 GRWMYEIHLHTKGVMQIGWASNSCQFNENSGVGDTKSSYGYDGSKQQIWHISTKKYGDKWQIGDV 196
            |:|:||:.:.::|:|||||.:.||:||:..|||||.:||.|||::.:.|:::|..||..|..||:
Human   133 GKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDI 197

  Fly   197 IGVTIDVDKEVIEYYRNGRSMGVAFNKLEKGPGISFFAAISLGYTQGIEANFGNRPFMYPVSGFQ 261
            :...||:|...:.:..||.|:|.||..|.:|.|:::|.||||.:.:.:..|||:||..|||:|::
Human   198 VSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVAGYR 262

  Fly   262 PLMARPILKLQRANLLMNYL-----VNLAGIFSK-YNAQSGMAPTNGADARVSTKKTVYCIFATL 320
            ||...|...|.||..|:...     |.|..:..: .:.:|......|....:.|...::..||.|
Human   263 PLQDPPSADLVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHIFHHFAPL 327

  Fly   321 LIEKFTNEIFDPYIIEDVLLRKISSMTNLASEKENSYSVLHGLLSLFWNYMEGDEIKFVLRKLVN 385
            |.:        .|::|.||:..:..:....:..: :.||:|.:|.|.|.:||..|::..|::|:.
Human   328 LRK--------VYLVEAVLMSFLLGIVEKGTPTQ-AQSVVHQVLDLLWLFMEDYEVQDCLKQLMM 383

  Fly   386 ALLG--TFTHTIQGLDYEKH--RQALGMLHCLCLHEQTRKYLLEGKLFKKHCLAFFLYI-HPL-- 443
            :||.  .|:..:..|..:.|  |..:.:|.    ||::||:||...||.......|.|| .||
Human   384 SLLRLYRFSPIVPDLGLQIHYLRLTIAILR----HEKSRKFLLSNVLFDVLRSVVFFYIKSPLRV 444

  Fly   444 EFYIMEELLPDSMAW-----TEGIDGPKEK------------YLNVVEKVRKVTEPLYTAQKDLL 491
            |...::||:|.:. |     .||.:..:.|            |....:::||..|.:...|..:|
Human   445 EEAGLQELIPTTW-WPHCSSREGKESTEMKEETAEERLRRRAYERGCQRLRKRIEVVEELQVQIL 508

  Fly   492 CTLMINSDGSRESPSSRSIFLSKLRRYVIDLSMEQRPFHAFFFMQSSIQHPLDAPV------ALA 550
            ..|:.|.| .....:||.|||:|.|:                |:|.:.....:.|:      .:.
Human   509 KLLLDNKD-DNGGEASRYIFLTKFRK----------------FLQENASGRGNMPMLCPPEYMVC 556

  Fly   551 FASILIDQTRSMFKDEMPTKN--------VEVNSDYFIDGTFDYMHFDRVGGVLSHLRKVHRGDI 607
            |...||...| .:.||....|        ..:....|.:|..||....|:||:||||||..:.|:
Human   557 FLHRLISALR-YYWDEYKASNPHASFSEEAYIPPQVFYNGKVDYFDLQRLGGLLSHLRKTLKDDL 620

  Fly   608 DAR---------LGSARTQQIYEDD-------RQNLRVNEVDTTLYLLGENINNVPVVGHTQGAN 656
            .::         |.|.....:.||:       ::.::...|...|.|......:.|.:|.   ||
Human   621 ASKANIVIDPLELQSTAMDDLDEDEEPAPAMAQRPMQALAVGGPLPLPRPGWLSSPTLGR---AN 682

  Fly   657 NTTYTHFLNT---------RPNSSTD--------------------------------SSPGNAD 680
                 .||:|         ||.|:::                                ..|....
Human   683 -----RFLSTAAVSLMTPRRPLSTSEKVKVRTLSVEQRTREDIEGSHWNEGLLLGRPPEEPEQPL 742

  Fly   681 MEASLCELLDLCIIFYYSAGHKYIVKIATVRDEIAALNEVLKETKFYREDIERKLGALEQHANVC 745
            .|.||.|:||..::.|..:.|:.:.|:..|.|::......|::|    ||..|:          |
Human   743 TENSLLEVLDGAVMMYNLSVHQQLGKMVGVSDDVNEYAMALRDT----EDKLRR----------C 793

  Fly   746 MNENHQHVMGELRSKFSQRQNVFATRSIALARKQVWLRGVALNNHRRSLLIWLLERMLRTLTTAS 810
             .:..:.::.||    ::.|.||:.:...|:|:..|:.....:..:...:.|||...|||:....
Human   794 -PKRRKDILAEL----TKSQKVFSEKLDHLSRRLAWVHATVYSQEKMLDIYWLLRVCLRTIEHGD 853

  Fly   811 NTGSLFSFVPEVYVNTLPILLDAVMDFSHHDLKAQF-------EASDAECSVNAAAEFLGIHSAD 868
            .|||||:|:||.|::.      |:..:|  .||..|       |....|.::...|..|..|.||
Human   854 RTGSLFAFMPEFYLSV------AINSYS--ALKNYFGPVHSMEELPGYEETLTRLAAILAKHFAD 910

  Fly   869 PRIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVRALLRPYENRAWGQSNWLLLRFWM 933
            .|||....:|||:|||.:..|:...:||:||..:..:.::||.||.|||.|.|.|:||:|:|.|.
Human   911 ARIVGTDIRDSLMQALASYVCYPHSLRAVERIPEEQRIAMVRNLLAPYEQRPWAQTNWILVRLWR 975

  Fly   934 GEGYAYKDSRQPSV----WQGGSLPLHQGLCRSRSRNETHTGLLHNVAPANPSKHFQRLIGAKLL 994
            |.|:.|:.:|.|.:    .:..:||..|..|                    ||...|:.: |.||
Human   976 GCGFGYRYTRLPHLLKTKLEDANLPSLQKPC--------------------PSTLLQQHM-ADLL 1019

  Fly   995 EDEP-FATAFLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLMRC 1058
            :..| .|.:||||||:||||||||||.::||||..|:|.|....:.:|||:|:.||:|:|||:|.
Human  1020 QQGPDVAPSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLLRV 1084

  Fly  1059 LEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYPIV 1123
            |||.||..|||..|.:||.|::||.|:.||::|||:|||.....|..||.:....|.:|.||||:
Human  1085 LEMTITLVPEIFLDWTRPTSEMLLRRLAQLLNQVLNRVTAERNLFDRVVTLRLPGLESVDHYPIL 1149

  Fly  1124 TAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGNFD 1188
            .|..|||:.|:.....|: |.|    .:...|.||.||..::.:.||:
Human  1150 VAVTGILVQLLVRGPASE-REQ----ATSVLLADPCFQLRSICYLLGQ----------------- 1192

  Fly  1189 PSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLL 1253
                |  :|......:|.|:..          :|:|..:..::|::|:..|.:::..|.......
Human  1193 ----P--EPPAPGTALPAPDRK----------RFSLQSYADYISADELAQVEQMLAHLTSASAQA 1241

  Fly  1254 SDITLP-SEDSLCPICCAKPITAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQTIE 1310
            :..:|| ||:.|||||.|.||:|||.||.|:||..||.||:||:|.||:|||||.::|
Human  1242 AAASLPTSEEDLCPICYAHPISAVFQPCGHKSCKACINQHLMNNKDCFFCKTTIVSVE 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kpc1	NP_650425.1	SPRY_RNF123	122..249	CDD:293940	54/126 (43%)
		RING-HC_RNF123	1263..1306	CDD:438203	28/42 (67%)
RNF123	NP_071347.2	SPRY_RNF123	123..250	CDD:293940	54/126 (43%)
		Interaction with NFKB1. /evidence=ECO:0000269|PubMed:34873064	968..974		3/5 (60%)
		RING-HC_RNF123	1252..1295	CDD:438203	28/42 (67%)