Protein Alignment CG6752 and rnf123

DIOPT Version :9

• Sequence 1: NP_001247116.1
• Gene: CG6752 / 41826
• FlyBaseID: FBgn0038296
• Length: 1332
• Species: Drosophila melanogaster
• Sequence 2: XP_002936521.2
• Gene: rnf123 / 100127191
• XenbaseID: XB-GENE-923134
• Length: 1306
• Species: Xenopus tropicalis
• Alignment Length: 1361
• Identity: 433/1361 - (31%)
• Similarity: 659/1361 - (48%)
• Gaps: 241/1361 - (17%)

  Fly    68 FQQIQTDSNEEIRRLYM--ET---------ESRIGPDLTIFDVDYTT----TVRVSSDRLALRSQ 117
            ||.::    |.:.||..  ||         |.|:||...:  :|:|:    .:.|..|.|.:...
 Frog    61 FQNLE----EHLERLVSAGETTEDDTDQAAEGRLGPSTVV--LDHTSGFEGLLLVDDDLLGVIGH 119

  Fly   118 GSFNTVRANCCVYGGRWMYEIHLHTKGVMQIGWASNSCQFNENSGVGDTKSSYGYDGSKQQIWHI 182
            .:|:::||..|||.|:|:||:.:.::|:|||||.:.||:||:..|||||..||.|||::.:.|::
 Frog   120 SNFSSIRATTCVYKGKWLYEVLISSQGLMQIGWCTLSCRFNQEEGVGDTPDSYAYDGNRVRKWNV 184

  Fly   183 STKKYGDKWQIGDVIGVTIDVDKEVIEYYRNGRSMGVAFNKLEKGPGISFFAAISLGYTQGIEAN 247
            :|..||..|..||::...||:|:..|.:..||.|:|.||:.:.:|.|:::|.||||.:.:.:..|
 Frog   185 TTTNYGKSWAAGDIVSCLIDLDEGTISFCLNGVSLGTAFSDISRGSGMAYFPAISLSFKESVAFN 249

  Fly   248 FGNRPFMYPVSGFQPLMARPILKLQRANLLMNYLVNL--AGIFSKYNAQSG-MAPTNGADARVST 309
            ||:||..|||.|::||...|...|.::..||.||.|.  .||    :.|.| :...:.|..::..
 Frog   250 FGSRPLRYPVEGYRPLQDPPTADLLKSQRLMGYLKNTLRTGI----DVQEGKLVDKDPATWQLQG 310

  Fly   310 KKTVYCIFATLLIEKFTNEIFDPYIIEDVLLRKISSMTNLASEKENSYSVLHGLLSLFWNYMEGD 374
            :.|:....|. :..:|...:...|::||||:..:..:.......|....:.| ||.|.|..||..
 Frog   311 EPTILITLAH-IFNQFAPLMCKVYLVEDVLINFLLGILEKGGAVEEHPLIQH-LLDLMWLLMEDY 373

  Fly   375 EIKFVLRKLVNALLGT--FTHTIQGLDYEKH--RQALGMLHCLCLHEQTRKYLLEGKLFK-KHCL 434
            ||...|::|:.:||..  |:..:..|..:.|  |..:.:|.    ||::|||||...||. ...:
 Frog   374 EIHECLKQLMMSLLRAYRFSPIVPDLGLQIHYLRLTIAILR----HEKSRKYLLSNVLFDVLRSV 434

  Fly   435 AFFLYIHPL--EFYIMEELLPDSMAW-----TEG--IDGPKEK----------YLNVVEKVRKVT 480
            .||....||  |...::||:|.:. |     .||  |..|.|:          |.....:::|..
 Frog   435 VFFFIKCPLRVEEAGLQELIPTTW-WPNRFNKEGKEIRDPSEESGEERLRRRAYERGCMRLKKRI 498

  Fly   481 EPLYTAQKDLLCTLMINSD-GSRESPSSRSIFLSKLRRYVIDLSMEQRPFHAFFFMQSSIQHPLD 544
            |.:...|..:|..|:.|.| |..|  :||.|||:|.|:                |:|.:..:..:
 Frog   499 EVVEELQVQILRLLLNNKDKGGGE--ASRYIFLNKFRK----------------FLQENASNRGN 545

  Fly   545 APV------ALAFASILIDQTRSMFKDEMPTKN-VEVNSD-------YFIDGTFDYMHFDRVGGV 595
            ..|      .:.|...||...||.: ||...:| :...||       .|.:|..||....|:||:
 Frog   546 PTVLCPPEYMVCFLHRLISALRSCW-DEYKIRNPLACGSDEAYVPPQLFYNGKVDYFDLQRLGGL 609

  Fly   596 LSHLRKVHRGDIDAR----LGSARTQQI------YEDDRQNLRVNEVDTTLYLLGENIN----NV 646
            ||||||..:.::.|:    :..:..|.:      .||:..|.........|.:.|....    :.
 Frog   610 LSHLRKTLKDELAAKANIVIDPSELQAVTMDDLEEEDESANTTAQRSSAALAIGGALARPSWLSS 674

  Fly   647 PVVGHTQGANNTTYTHFLN-TRPNSSTDS-----------------------------SPGNAD- 680
            |.:|......:|.....:| .||..:.|.                             .|..||
 Frog   675 PTLGRANRFLSTAAVSLMNPRRPLGALDKVKVRSLSVDQRTEDDIEGQHGNDGLLLGRPPEEADT 739

  Fly   681 --MEASLCELLDLCIIFYYSAGHKYIVKIATVRDEIAALNEVLKETKFYREDIERKLGALEQHAN 743
              .|.||.|:||..::.|..:.|:.:.|:..|.|::......||:|:   |.|:|
 Frog   740 VITENSLLEILDGAVMMYNLSVHQQLGKMVGVSDDVNEYALALKDTE---EKIKR---------- 791

  Fly   744 VCMNENHQHVMGELRSKFSQRQNVFATRSIALARKQVWLRGVALNNHRRSLLIWLLERMLRTLTT 808
             | .:....:|.||    .:.|.||:.:...|:|:..|:.....:..:...:.|||:..||::..
 Frog   792 -C-PKRRADIMDEL----VKSQRVFSEKLNHLSRRLAWINVTIYSKDKMQDIYWLLQVCLRSIEH 850

  Fly   809 ASNTGSLFSFVPEVYVNTLPILLDAVMDFSHHDLKAQF-------EASDAECSVNAAAEFLGIHS 866
            |..|||||:|:||.|:|        |...|::.||..|       |....|.::...|..|..|.
 Frog   851 ADRTGSLFAFMPEFYLN--------VAMNSYNALKNYFSPVSSMEELQGYEETLTRLATILAKHF 907

  Fly   867 ADPRIVLASCKDSLLQALGTLTCHKSGVRALERTSKRSQASLVRALLRPYENRAWGQSNWLLLRF 931
            ||||||....||||:|||.:..|:...:||:||.|:..|.|:::.||.|||.|.|.|:||:|:|.
 Frog   908 ADPRIVGTDIKDSLMQALASYVCYPHSLRAVERISEEQQISMMKNLLAPYEQRPWAQTNWILVRL 972

  Fly   932 WMGEGYAYKDSRQPSVW----QGGSLPLHQGLCRSRSRNETHTGLLHNVAPANPSKHFQRLIGAK 992
            |.|.|:.|:.:|.|.:.    :..:||..|..|.|.        ||.|        |.     |:
 Frog   973 WRGCGFGYRYTRLPHLLKTKPEDANLPSLQKPCPST--------LLQN--------HM-----AE 1016

  Fly   993 LLEDEP-FATAFLNSVLSQLNWAFSEFILLLQEIQNTAQRQENTLFEPKQLKICSMCFELTVSLM 1056
            ||..:| .|::||||||:||||||||||.::||||..|:|.|....:.:|||:|:.||:|:|||:
 Frog  1017 LLRGDPELASSFLNSVLNQLNWAFSEFIGMIQEIQQAAERLERNFVDSRQLKVCATCFDLSVSLL 1081

  Fly  1057 RCLEMVITTAPEIVTDESRPNSDLLLNRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYP 1121
            |.|||.:|..|:|..|.||.:|:|||.|:.||::|||:|||.....|..||::....|.:|.|||
 Frog  1082 RVLEMTVTLVPDIFLDWSRSSSELLLRRLAQLLNQVLNRVTAERNLFDRVVNLRLPGLESVDHYP 1146

  Fly  1122 IVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNIPRGN 1186
            |:.|..|||:.|:     .|...|.:.|.:...|.||.||..::::.||:....:|       |.
 Frog  1147 ILVAVTGILVRLL-----VDSSSQGIQRATAVLLADPCFQLRSIQYLLGQAEQSVL-------GA 1199

  Fly  1187 FDPSS-RPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQ 1250
            ..||: :.|                           |:|..:..::::||:..|..::..|..:.
 Frog  1200 GPPSADKKH---------------------------FSLQAYTDYINAEELGKVSNMLAHLSEES 1237

  Fly  1251 TLLSDITLP-SEDSLCPICCAKPITAVFTPCKHQSCSDCIMQHMMNSKVCFYCKTTIQTIE 1310
            ...:..|.| ||:.|||||.|.||:|||.||.|:||..||.||:||:|.||:||.||..::
 Frog  1238 KQAAAATQPTSEEDLCPICYAHPISAVFKPCSHKSCKACINQHLMNNKDCFFCKATITGVD 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6752	NP_001247116.1	SPRY_RNF123	122..249	CDD:293940	54/126 (43%)
		zf-C3HC4_3	1261..1309	CDD:290631	30/47 (64%)
rnf123	XP_002936521.2	SPRY_RNF123	124..251	CDD:293940	54/126 (43%)
		RING-HC_RNF123	1251..1291	CDD:319455	25/39 (64%)
		RING-HC finger (C3HC4-type)	1253..1290	CDD:319455	24/36 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	355	1.000	Domainoid score	I986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11112
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1044
OMA	1	1.010	-	-		QHG60087
OrthoDB	1	1.010	-	-		D133044at33208
OrthoFinder	1	1.000	-	-		FOG0006357
OrthoInspector	1	1.000	-	-		oto104259
Panther	1	1.100	-	-	LDO	PTHR13363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5412
SonicParanoid	1	1.000	-	-		X5310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110