DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc88E and Phlpp1

DIOPT Version :9

Sequence 1:NP_001036711.1 Gene:Gyc88E / 41825 FlyBaseID:FBgn0038295 Length:1097 Species:Drosophila melanogaster
Sequence 2:NP_598582.3 Gene:Phlpp1 / 98432 MGIID:2138327 Length:1687 Species:Mus musculus


Alignment Length:1121 Identity:221/1121 - (19%)
Similarity:383/1121 - (34%) Gaps:351/1121 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 GRHMRDFLNGLDNLHE--YLKFSY----------PRMRAPSFIC--ENETKQGLTLHYRSKRRGF 140
            |..::.....|:::|:  ||..|:          .::.|...:|  .|..:   ||..::.||  
Mouse   702 GNFLQSLPAELESMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCVE---TLRLQALRR-- 761

  Fly   141 VYYTMGQIREVARYFYHKEMHIELVREEILFDTV----HVTFQLTF-DNRAFTLASLAMTREE-- 198
                |..|:       |.::.:.::| :::.|.|    ||| ||.. ||:...|.::.....|  
Mouse   762 ----MPHIK-------HVDLRLNILR-KLMADEVDFVQHVT-QLDLRDNKLGDLDAMIFNNIEVL 813

  Fly   199 -----------------KHLPISAHVL--FEIFPF------------CMVFGADMVVRS------ 226
                             |.|..|::.|  .:::|.            |:....:.|..|      
Mouse   814 HCERNQLVTLNVCGYFLKALYASSNELAQLDVYPVPNYLSYMDVSRNCLESVPEWVCESRKLEVL 878

  Fly   227 -IGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQ 290
             ||::.:..||..|....:     :|.|:|..     ||...:.|.:      ||..|:..| :|
Mouse   879 DIGHNQICELPARLFCNSS-----LRKLLAGH-----NRLARLPERL------ERTSVEVLD-VQ 926

  Fly   291 HEDGSEPEKSLRLKGQMVYMEN--WRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAG 353
            |...:|...:|.:|...:...|  ...:..|....:.:.||.|...||:.:..:.|....| |.|
Mouse   927 HNQITELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNCLTDKCVPL-LTG 990

  Fly   354 TQQSVELKLALDQEQ----QKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTC 414
            ..:...|.:|.::.|    .|..||||.     ||:..:...| :.||..:.: .||....|...
Mouse   991 HPRLKILHMAYNRLQSFPASKMAKLEEL-----EEIDISGNKL-KAIPTTIMN-CRRMHTVIAHS 1048

  Fly   415 EMFDSVSILFSDIVTFTEI------CSRITPMEVVSML-----------NAMYSIFDKLTE-RNS 461
            ...:    :|.:::...|:      |:.::.:.:...|           |...::..|..| .|:
Mouse  1049 NCIE----VFPEVMQLPEVKCVDLSCNELSEITLPENLPPKLQELDLTGNPRLALDHKSLELLNN 1109

  Fly   462 V--YKVE--TIGDAYMVVAGAP-------DKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIR 515
            :  :|::  :.|||    :|||       .:.:....::|..||. |:...|.::...|      
Mouse  1110 IRCFKIDQPSAGDA----SGAPAVWSHGYTEASGVKNKLCVAALS-VNNFRDNREALYG------ 1163

  Fly   516 VGVHSGAVVAGIVGLKMP--RYCLFGD--------TVNTASRMESTSIAMKVHISESTKVLIGPN 570
                   |..|...:::|  ..|...|        |.|....|.:|.|.|:..:..:.:.|.|..
Mouse  1164 -------VFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAA 1221

  Fly   571 YKI-IERGEIDVKGKGTM----------------------GTYWLEERENRLPLQ---------- 602
            ... |:...:|:.|..|:                      .:|.:...|.|..::          
Mouse  1222 VLCHIKPDPVDLGGSFTLTSANVGKCQTVLCRNGKPLSLSRSYIMSCEEERKRIKQHKAIITEDG 1286

  Fly   603 ----LTAALQV------HPLSPVPPTPTPKTKAIMPP------VSKPLTPMMPVSVSLAASMPTS 651
                :|.:.::      ||  .|.|.|..::..:.|.      .||.|...:.:..::.|   ..
Mouse  1287 KVNGVTESTRILGYTFLHP--SVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIDEAVEA---VR 1346

  Fly   652 NVPAVDVMASSSSISGLALTAAAAAHMSLHHQAVVAEALTGASVEVALPSVASGATGAAAGGGAP 716
            |||  |.:|::..:..||  .:...|.|:  .|||        |::::...:......:|||..|
Mouse  1347 NVP--DALAAAKKLCTLA--QSYGCHDSI--SAVV--------VQLSVTEDSFCCCELSAGGSMP 1397

  Fly   717 SDDRNSRIYSPVTFKDVARRSVANSPVRSCAQPDQERRRESRSNSTGHVFMRTPSEIFGSLILDT 781
            ..       ||..|.......:.:.|......|         |:|:|     ..|||  |..|.|
Mouse  1398 PP-------SPGIFPPSVNMVIKDRPSDGLGVP---------SSSSG-----MASEI--SSELST 1439

  Fly   782 EEFLEDLQISRSSLANNNNNQSPCGF--SPTPPFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPP 844
            .|.       .|.:.:..:::.|.|.  ..:|.:                  |.|...|......
Mouse  1440 SEM-------SSEVGSTASDEPPSGVLNESSPAY------------------PNEQRCMLHPVCL 1479

  Fly   845 STAPARETASCSSAS------LDRDKATKLKKITFSNSSSLDATTPTALAAVVCPMRTKSPPMAV 903
            |.:..|:.:|.:.:|      ||.|....::.: |||.|.::....     :.| .|.|..... 
Mouse  1480 SNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGV-FSNGSRVEVEVD-----IHC-SRAKEKERQ- 1536

  Fly   904 APVMHMVQASTSKGD-GQRPGSKDSVSSISLHSPPPHRSNSAPARPHSMSKAARKAFLAAKQTKA 967
               .|::|......| |....:.:..|.:|                       :||..:|..|..
Mouse  1537 ---QHLLQVPAEASDEGIVISANEDESGLS-----------------------KKADFSAVGTIG 1575

  Fly   968 MEKLDKMIEEVQEVESQSVAKAANMRLALYGHDGGGDLAAGGCP----LFLPPP----------- 1017
            ..:.:..:.. ||.....:..||:..|    ...||..||...|    .|:.||           
Mouse  1576 RRRANGSVAP-QERSHNVIEVAADAPL----RKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMK 1635

  Fly  1018 ---PQQQQQQQQSLMP 1030
               .||||||||.|.|
Mouse  1636 HHQEQQQQQQQQQLPP 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc88ENP_001036711.1 HNOB 2..164 CDD:311572 16/87 (18%)
HNOBA 201..404 CDD:311573 51/229 (22%)
CYCc 383..571 CDD:214485 42/226 (19%)
Herpes_ICP4_C 794..>955 CDD:332854 26/169 (15%)
Phlpp1NP_598582.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..406
PH_PHLPP-like 491..587 CDD:270131
PH 511..592 CDD:278594
LRR_RI 581..885 CDD:238064 38/200 (19%)
LRR_8 594..659 CDD:290566
LRR 1 594..615
leucine-rich repeat 597..617 CDD:275380
LRR 2 617..638
leucine-rich repeat 618..648 CDD:275380
LRR_8 647..726 CDD:290566 6/23 (26%)
LRR 3 648..669
LRR 4 671..692
leucine-rich repeat 672..694 CDD:275380
LRR 5 694..715 2/12 (17%)
leucine-rich repeat 695..717 CDD:275380 2/14 (14%)
LRR 6 717..739 3/21 (14%)
leucine-rich repeat 718..740 CDD:275380 3/21 (14%)
LRR 7 740..760 5/22 (23%)
leucine-rich repeat 741..764 CDD:275380 7/31 (23%)
LRR 8 764..785 5/28 (18%)
LRR_RI 768..1030 CDD:238064 62/287 (22%)
leucine-rich repeat 768..788 CDD:275380 3/20 (15%)
LRR 9 788..809 8/21 (38%)
leucine-rich repeat 789..809 CDD:275380 7/20 (35%)
leucine-rich repeat 810..851 CDD:275380 6/40 (15%)
LRR 10 829..850 5/20 (25%)
LRR 11 851..872 2/20 (10%)
leucine-rich repeat 852..874 CDD:275380 3/21 (14%)
LRR 12 874..895 5/20 (25%)
leucine-rich repeat 875..897 CDD:275380 5/21 (24%)
LRR_8 896..954 CDD:290566 16/74 (22%)
LRR 13 897..918 7/36 (19%)
leucine-rich repeat 898..919 CDD:275380 8/31 (26%)
LRR 14 919..940 6/21 (29%)
leucine-rich repeat 920..943 CDD:275380 7/23 (30%)
LRR 15 943..964 2/20 (10%)
leucine-rich repeat 944..967 CDD:275380 2/22 (9%)
LRR 16 969..989 5/20 (25%)
LRR_8 970..1028 CDD:290566 16/63 (25%)
leucine-rich repeat 970..993 CDD:275380 6/23 (26%)
LRR 17 993..1014 4/20 (20%)
leucine-rich repeat 994..1017 CDD:275380 6/22 (27%)
LRR 18 1017..1038 6/27 (22%)
LRR 19 1040..1061 3/24 (13%)
LRR 20 1062..1083 2/20 (10%)
leucine-rich repeat 1063..1085 CDD:275380 2/21 (10%)
LRR 21 1085..1106 2/20 (10%)
PP2Cc 1124..1376 CDD:214625 52/284 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1414..1465 15/73 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1604..1687 18/48 (38%)
PDZ-binding 1685..1687
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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