DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	236	Identity:	108/236 - (45%)
Similarity:	160/236 - (67%)	Gaps:	11/236 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 LEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGEN--PIDTCEMFDSVSILFSDIVTFTEICSR 436
            :||..|.|..|.|:.::||..|:|..|.::|..|::  |    |.|:||:|.|||||.||::||.
Mouse   856 VEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEP----EHFESVTIFFSDIVGFTKLCSL 916

  Fly   437 ITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKD-ANHAERVCDMALDMVDAI 500
            .:|::||.:||.:||:||...:.:.|||||||||||||.:|.|.:: |.||:.:..|||.::...
Mouse   917 SSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVT 981

  Fly   501 TDLK-DPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST- 563
            |..: .....:.|::|:|:|:|.||||:||:.||||||||||||.||||||:|:.:::|:|:||
Mouse   982 THFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTA 1046

  Fly   564 -KVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQL 603
             .:|....|.:.:||.|.|||||...|:||:.::. .|:.|
Mouse  1047 GALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDG-FPVPL 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	11/29 (38%)
		CYCc	383..571	CDD:214485	90/193 (47%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894
		CYCc	865..1055	CDD:214485	90/193 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810