Protein Alignment Gyc88E and Gucy1a2

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_076446.1
• Gene: Gucy1a2 / 66012
• RGDID: 621655
• Length: 730
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 185/593 - (31%)
• Similarity: 305/593 - (51%)
• Gaps: 61/593 - (10%)

  Fly    57 VLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPR---MRAPS 118
            |||:..::..::.|..|........ :|||..:|..::||.||.|.|.|:::.|:.:   :.:||
  Rat   159 VLGLKFQEIQERFGEEFFKICFDEN-ERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPS 222

  Fly   119 FICENETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELV-REEILFDTVHVTFQLTF 182
            |:|:...:..|.|||........:..:|.|:...:..||..:.:|.: .|:...|.   :....:
  Rat   223 FLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDG---STPSNY 284

  Fly   183 DNRAFTLASLAMTREEKHLP-----------ISAHVLFEIFPFCMVFGADMVVRSIGNSLMVIL- 235
            ....|.:.....|:..|::|           ||.:.....|||.::|..:|||..:|..|...|
  Rat   285 SCLTFLIKECETTQITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLR 349

  Fly   236 ---PELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEP 297
               .::|  |....|::|.|.:...|..:|.|.:..| ::...|  |.....|||
  Rat   350 CDNHKVL--KFEDCFEIVSPKVNATFDRVLLRLSTPF-VIRTKP--EASGTDNED---------- 399

  Fly   298 EKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE--L 360
             |.:.:||||:::.....|:|||:|.:..|..||..||:::|:.:||.:||::|.|.|...:  |
  Rat   400 -KVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGL 463

  Fly   361 KLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFS 425
            |..:|   :....||::.:.|:||.::|.:|||.:.|..||.:|.:.:..  ....||.|::|||
  Rat   464 KKRMD---KLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQV--QARKFDDVTMLFS 523

  Fly   426 DIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVC 490
            |||.||.||::.|||:|:||||.:|:.||.......:||||||||||.|.:|...|...||:.:.
  Rat   524 DIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIA 588

  Fly   491 DMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAM 555
            .|||.|::...::..|. |:.:::|:|:|||:|:||:||::||||||||:.|..||:.||.|...
  Rat   589 LMALKMMELSEEVLTPD-GRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPR 652

  Fly   556 KVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAALQVHPL--SPVPPT 618
            :::||.:|       |::::|     :...|......||..:..|.::........|  .|.||.
  Rat   653 RINISPTT-------YQLLKR-----EDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPK 705

  Fly   619 PTPKTKAI 626
            |:..:..|
  Rat   706 PSLSSSRI 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	29/108 (27%)
		HNOBA	201..404	CDD:462234	65/219 (30%)
		CYCc	383..571	CDD:214485	82/187 (44%)
		PHA03307	794..>955	CDD:223039
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:462233	29/109 (27%)
		HNOBA	314..501	CDD:462234	62/205 (30%)
		Guanylate_cyc	512..696	CDD:425528	78/196 (40%)