DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Adcy3

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_570135.2	Gene:	Adcy3 / 64508	RGDID:	71009	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	130/538 - (24%)
Similarity:	232/538 - (43%)	Gaps:	143/538 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 QLTFDNRAFTLASLAMT--REEKHLPISAHVLFEIFPFC-------MVFGAD----MVVRSIGNS 230
            :|||...  :|.:|..|  :.::|..:...|:|.....|       :||.:|    ::|..:|..
  Rat    54 RLTFVPE--SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLV 116

  Fly   231 LMVI---------LPELLGKKIT---AWFDLVRPLIA---------------------FKFQTIL 262
            |.:|         ||:.:.:|:.   .|..:...:.:                     |.|...:
  Rat   117 LDIILFVLCKKGLLPDRVSRKVVPYLLWLLITAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFI 181

  Fly   263 NRTNNIFELVTVDPVTERFDVQNEDLL------QHEDGSEPEKSLR--LKGQMVYMENWRMIMFL 319
            ....::..:|.:..|:   .|.:..:|      |.:|..|..:.||  |....:|:
  Rat   182 TLPLSLSPIVIISVVS---CVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYL--------- 234

  Fly   320 GTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEE 384
                     ..|..|  |....|.|..........:||:|:|:.|:::.|:.
  Rat   235 ---------CAIIVG--IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQ------------- 275

  Fly   385 MRRTDELLYQMIPKQVADRL---------RRGENPIDTCEMF--DSVSILFSDIVTFTEICSRIT 438
                :.|:..::||.|||.:         ::.:...:|..|:  ::|||||:|||.||::.|..:
  Rat   276 ----ENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACS 336

  Fly   439 PMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCD--MALDMVDAIT 501
            ..|:|.:||.:::.||||..:....:::.:||.|..:.|.||...:||  ||.  |.|.||:||:
  Rat   337 AQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHA--VCSILMGLAMVEAIS 399

  Fly   502 DLKDPS-TGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKV 565
            .:::.: ||  :.:|||||:|.|:.|::|.|..:|.::...|..|::||:..|..:||||:||..
  Rat   400 YVREKTKTG--VDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMD 462

  Fly   566 LIGPNYKIIERGEIDVK-GKGTMGTYWLEERENRLPLQLTAALQVHPLSPVPPTPTPKTK----- 624
            .:        :||.||: |.|.....:|:|:.....|.:.:..:|           .||.
  Rat   463 CL--------KGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPEV-----------KKTAQNGLN 508

  Fly   625 -AIMP---PVSKPLTPMM 638
             :.:|   |.|||.:|.:
  Rat   509 GSALPNGAPASKPSSPAL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	44/254 (17%)
		CYCc	383..571	CDD:214485	67/201 (33%)
		Herpes_ICP4_C	794..>955	CDD:332854
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	51/290 (18%)
		Guanylate_cyc	310..494	CDD:306677	69/195 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..563		6/23 (26%)
		Guanylate_cyc	914..1121	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810