Protein Alignment Gyc88E and Gucy1a1

DIOPT Version :9

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_001343916.1
• Gene: Gucy1a1 / 60596
• MGIID: 1926562
• Length: 691
• Species: Mus musculus
• Alignment Length: 641
• Identity: 188/641 - (29%)
• Similarity: 307/641 - (47%)
• Gaps: 103/641 - (16%)

  Fly     7 ENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMGV 71
            |.|:..::....:.|.|:.|:.:..:.             |:|:..:.....|.......|.:|.
Mouse    87 ERLNLALQRTLAKHKIEENRKSSEKED-------------LEKIIAEEAIAAGAPVEALKDSLGE 138

  Fly    72 YFVGFVGQYGYD-RVLSVLGRHMRDFLNGLDNLHEYLKFS--------YPRMRAPSFICENETKQ 127
            ..  |...|..| .:|.|:|..::||||....|   ||.|        ..|:...|.:|.::.:.
Mouse   139 EL--FKICYEEDEHILGVVGGTLKDFLNSFSTL---LKQSSHCQEAERRGRLEDASILCLDKDQD 198

  Fly   128 GLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIEL--------------VREEILFDTVHVTF 178
            .|.::|...:|.......|.|:..||..|  |.|:|:              |.:..|..:|||
Mouse   199 FLNVYYFFPKRTTALLLPGIIKAAARILY--ESHVEVSLMPPCFRSDCTEFVNQPYLLYSVHV-- 259

  Fly   179 QLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSL--MVILPELLGK 241
                   ..|..||:..:.:..|.|.|.:..:.|||..:...|:.:..:||.:  :|...:..||
Mouse   260 -------KSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGK 317

  Fly   242 -KITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLR--- 302
             ....:|:::.|.|...|..|:...|..| ::.|    .|:|            :..:||.|
Mouse   318 PNFEEFFEILTPKINQTFSGIMTMLNMQF-VIRV----RRWD------------NSVKKSSRVMD 365

  Fly   303 LKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE--LKLALD 365
            |||||:|:.....|:|||:|.:..|......|||::|:.:|:..||::|.|.|...:  ||..|.
Mouse   366 LKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLG 430

  Fly   366 QEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTF 430
               :....||.:.:.|:||.:||.:||..:.|.:||.:|.:|:  |...:.|..|::||||||.|
Mouse   431 ---KLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQ--IVQAKKFSEVTMLFSDIVGF 490

  Fly   431 TEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALD 495
            |.|||:.:|::|::||||:|:.||:......|||||||||||.|..|...:...||.::..|||.
Mouse   491 TAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALK 555

  Fly   496 MVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHIS 560
            |::...::..|. |:.:::|:|:|||:|.||:||:|||||||||:.|..|::.||.|:..|:::|
Mouse   556 MMELSNEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619

  Fly   561 ESTKVLIG--PNYKIIERGE--------IDVKG----------KGTMGTYWLEERE 596
            .:|..|:.  |.:....|..        .|:.|          :|.....|.::::
Mouse   620 PTTYRLLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYHHQGPNSKPWFQDKD 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	37/165 (22%)
		HNOBA	201..404	CDD:311573	62/210 (30%)
		CYCc	383..571	CDD:214485	84/189 (44%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	61/208 (29%)
		Guanylate_cyc	472..643	CDD:306677	73/171 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810