DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and CG34357

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	217/856 - (25%)
Similarity:	341/856 - (39%)	Gaps:	255/856 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELV 272
            |.:::.|.::. .::|||.....::.:.||.:..||.....|:||.::
  Fly   956 LGDVYSFGIIM-QEVVVRGEPYCMLSLSPEEIIVKIKKPPPLIRPSVS----------------- 1002

  Fly   273 TVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVM-PDLTSLITTGLY 336
                                .|:.|.:::.:..|.     |     ...|.| ||..|:
  Fly  1003 --------------------KGAAPPEAINIMRQC-----W-----AEQPDMRPDFNSV------ 1031

  Fly   337 INDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMR----LLDEEMRRTDELLYQMIP 397
                    :.|..||...::...:.......::.|..|||.:|    .||.|.::|::||.:|:|
  Fly  1032 --------YERFKMLNHGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLP 1088

  Fly   398 KQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSV 462
            ..||::|:.| ..:|. |.|..|:|.|||||.||.|.:..:|::||.:||.:|:|||......:|
  Fly  1089 SSVAEKLKMG-LAVDP-EEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNV 1151

  Fly   463 YKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDA-----ITDLKDPSTGQHLRIRVGVHSGA 522
            |||||||||||||:|.|.|..:|||::..||||::..     :..|    .|..|::|:|:|:|.
  Fly  1152 YKVETIGDAYMVVSGLPVKIPDHAEQIATMALDLLHQSGRFNVKHL----PGVPLQLRIGLHTGP 1212

  Fly   523 VVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGP--NYKIIERGEIDVKGKG 585
            ..||:|||.||||||||||||||||||||..:.::|:|:.|:..:..  .|.|..||.||:||||
  Fly  1213 CCAGVVGLTMPRYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKG 1277

  Fly   586 TMGTYWLEERE------------------------NRLPLQLTA---ALQVHPLSP--------- 614
            .|.|:||..::                        |.:.|:..|   ....:|.|.
  Fly  1278 MMNTFWLLGKKGFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGES 1342

  Fly   615 -------VPPT----------------PTPKTKAIMPPVSKPLTPMMPVSVSLAASMPTS----- 651
                   .|||                .:..|..|.|  :..|.|..|...:.:::.|.|
  Fly  1343 VEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTISP--NATLCPEFPGKTTPSSTSPQSRKLSE 1405

  Fly   652 -------NVPAVDVMASSSSISGLALTAAAAAHMSL-----HHQAV------VAEALTGASVEVA 698
                   |..:.:.:.||:..|...|.......|.|     |::.:      :.:...|   :..
  Fly  1406 LTPENLLNPNSFNRLPSSTGGSSSRLYKKIEEMMDLSSPYNHYKCLSPSESNLTQFYDG---KYL 1467

  Fly   699 LPSVASGATGAAAGGGAPSD---------DRNSRIYSPVTFKDVARRSVANSPVRSCAQPDQERR 754
            ..|||.||.|..|||||.:.         ...||..|......:.||..      |..:.||:.:
  Fly  1468 YGSVAGGAGGGQAGGGACASIALSGSGCGGGASRFDSKPGSSRLLRRQF------SLDRDDQQAK 1526

  Fly   755 RESRSNSTGHVFM-RTPSEIFG-------SLILDTEEFLEDLQISRSSLANNNNNQSPCGFSPTP 811
            .|.:.:.  |... .|.|.:.|       |.:||. ..|.|...|.......::.|:....:
  Fly  1527 GEQQHHQ--HSLQANTYSGLVGGCGGGVKSSMLDI-PLLHDTTRSPKGTLTRSHKQNSASIT--- 1585

  Fly   812 PFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSASLDRDKATKLKKITFSNS 876
                                 ::|..::::      |....:|...:|||
  Fly  1586 ---------------------QDLEKIEEI------PLSPASSQHHSSLD--------------- 1608

  Fly   877 SSLDATTPTALAAVVCPMRTKSPPMAVAPV------------MHMVQASTSKG-----DGQRPGS 924
            |:|:.:.|:.|.|...|:...|||...||.            .|...:::|.|     :|..||.
  Fly  1609 SNLNRSPPSTLEAQSPPLPPMSPPQLSAPTSPAPSRTLNGIYAHNSNSTSSHGAANNNNGTHPGP 1673

  Fly   925 KDSVSSISLHS 935
            :.::::..|.|
  Fly  1674 ELTLNAEQLLS 1684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	39/200 (20%)
		CYCc	383..571	CDD:214485	91/194 (47%)
		Herpes_ICP4_C	794..>955	CDD:332854	26/159 (16%)
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	24/146 (16%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	92/197 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810