DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and adcy1b

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	399	Identity:	116/399 - (29%)
Similarity:	188/399 - (47%)	Gaps:	72/399 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 MIMFLGTPVMP-DLTSLITTGLYINDLSMHDFSR----------------DLMLAGT-----QQS 357
            |.:||....:| .:..|:...|||..|.:..|.|                .|:|..|     .:.
Zfish   720 MALFLRVSWIPKTILLLLLLVLYITILELSGFRRASGWALLSVRGLEPLLSLLLFSTAVALHSRQ 784

  Fly   358 VELKLALD-----QEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADR--LRRGENPIDTCE 415
            ::|||.||     |.:::...:|:..  ||.:     .:|:.::|..||..  |....|.....:
Zfish   785 LDLKLRLDFLWATQAEEERDGMEKVK--LDNK-----RILFNLLPVHVAQHFLLSNPRNMDLYYQ 842

  Fly   416 MFDSVSILFSDIVTFT----EICSRITPMEVVSMLNAMYSIFDKLTER---NSVYKVETIGDAYM 473
            .:..|.:||:.|..|.    |:......:|.:.:||.:.:.||:|.::   ..:.|::|||..||
Zfish   843 SYAQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKECYKDIEKIKTIGSTYM 907

  Fly   474 VVAG--------APDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGL 530
            ...|        |....|.|...:.|.|::|.|.:.::...|....: :|||::.|.||||::|.
Zfish   908 SAVGLVPTIGTKAKKSTATHLSTIADFAIEMFDVLDEINYQSYNDFV-LRVGINVGPVVAGVIGA 971

  Fly   531 KMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEER 595
            :.|:|.::|:|||.||||:||.:..|:.::|....|:..||.::.||.:.|||||.|.||:||.:
Zfish   972 RRPQYDIWGNTVNVASRMDSTGVPGKIQVTEDVYRLLQNNYDLMCRGNVSVKGKGQMLTYFLEGK 1036

  Fly   596 EN----RLPLQLTAALQ--VHPLSPVPPTPTPKTKAIMPPVSKPLTPMMPVSVSLAASM------ 648
            ..    |.| ..|..|:  ||.::   .|.:.:|||  ..||. .|..:.|.|.|::|.
Zfish  1037 AQDPGIRAP-HHTGGLERRVHAIA---RTSSTQTKA--GSVSS-ATSGLAVRVGLSSSFHGPHGH 1094

  Fly   649 -PTSNVPAV 656
             .|:|||.|
Zfish  1095 SNTTNVPTV 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	27/117 (23%)
		CYCc	383..571	CDD:214485	57/204 (28%)
		Herpes_ICP4_C	794..>955	CDD:332854
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831
		CYCc	236..431	CDD:214485
		Guanylate_cyc	272..454	CDD:278633
		DUF1053	498..585	CDD:283888
		CYCc	806..1012	CDD:214485	60/213 (28%)
		Guanylate_cyc	839..1035	CDD:278633	64/196 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810