DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and si:dkey-206f10.1

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_009293230.1	Gene:	si:dkey-206f10.1 / 560719	ZFINID:	ZDB-GENE-041014-154	Length:	1187	Species:	Danio rerio

Alignment Length:	628	Identity:	135/628 - (21%)
Similarity:	252/628 - (40%)	Gaps:	158/628 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GYDR--------VLSVLGRHMRDFLNGLDNLH----------------EYLKFSYPRMRAPSFIC 121
            ||:|        :.:.|..|..|.||.::..|                .:...||.::...| .|
Zfish   547 GYERNEFLRKHNIDTFLICHKEDDLNEMEAEHPKTRHNNRPWNKEILASFSNGSYTQLPTSS-AC 610

  Fly   122 ENETKQ-----GLTLHYRSKRRGFVYYTMGQ--IREVARYFYHKEMHIE----LVREEILFDTVH 175
            .:.:|:     ...:..||..|      |.|  |..|...|  |:.|||    .||:|:....:.
Zfish   611 RSMSKEINKRIEHAIDLRSSER------MRQEHITPVTLVF--KDAHIEEKFSQVRDEMFKTNLV 667

  Fly   176 VTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELLG 240
            .:|          :..|.:...:..:|:....|:.:..||:..        :|..|::::  :|.
Zfish   668 CSF----------IMLLLLMAVQALIPVPRMYLWTVLQFCLFL--------LGYLLLLVM--VLA 712

  Fly   241 KKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLR-LK 304
            ::...     .|.:..:|...::..|::..|:|:..:...|.:...|::........|.|.| .:
Zfish   713 EEFKH-----SPGVLQQFCCWIHENNSMRNLLTITAIAMNFGMALFDMMWCNSSEMKEISTRETE 772

  Fly   305 GQMVYMENWRMIMFLGTPVMPDLTSLITTGLYIN---------------------DLSMH----- 343
            |.....:......:....|:..:.|::|..:::.                     ::|.|
Zfish   773 GYKAGQKPLTACTYPEVFVLSGVVSMVTCAVFLRMSSLLKLTILLFVVAVYTYFIEVSFHMLYVH 837

  Fly   344 -----DFSRDLML-------------------------AGTQQSVELKLALDQEQQKSKKLEESM 378
                 ..||...|                         |.|:.....:|...||.|:.:.|.|
Zfish   838 QQEHEHLSRSHFLRRKGVSILLMAMFMIAVLYNGRRWEATTRLDFLWRLQAQQEVQEMRDLRE-- 900

  Fly   379 RLLDEEMRRTDELLYQMIPKQVADR-LRRGENPIDT-CEMFDSVSILFSDIVTFTEICS----RI 437
                    ..:.||:.::|..||.. |.|..|..:. .:.:|.|.::|:.|..|.:...    :.
Zfish   901 --------HNECLLHNILPAHVARHFLERNRNDQELYSQSYDEVGVMFASIAGFNDYYEQKEIKH 957

  Fly   438 TPMEVVSMLNAMYSIFDKLTERN---SVYKVETIGDAYMVVAG-APDK------DANHAERVCDM 492
            ..:|.:.:||.:.:.||:|.|.:   .:.|::|||..||..:| :|||      |.:|...:...
Zfish   958 EGVECLKLLNEIIADFDELLEESYFLDIEKIKTIGSCYMAASGLSPDKQSRVVNDWHHLSELVLF 1022

  Fly   493 ALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKV 557
            ||.|.:.:.::...|. .:.::|||:..|.||||::|...|:|.::|.|||.||||:||.::.::
Zfish  1023 ALAMQETLREINKHSM-NNFQLRVGIAHGPVVAGVIGATKPQYDIWGMTVNLASRMDSTGVSGRI 1086

  Fly   558 HISESTKVLIGPNYKIIE-RGEIDVKG----KGTMGTYWLEER 595
            .:.|:|:.::.....::| ||||.:||    ||.:.||::..:
Zfish  1087 QVPEATRNILADWGFVLELRGEIYIKGVSERKGRVRTYFISTK 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	26/117 (22%)
		HNOBA	201..404	CDD:311573	39/260 (15%)
		CYCc	383..571	CDD:214485	59/203 (29%)
		Herpes_ICP4_C	794..>955	CDD:332854
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:292831
		CYCc	343..538	CDD:214485
		Guanylate_cyc	382..564	CDD:278633	3/16 (19%)
		DUF1053	<611..661	CDD:283888	15/57 (26%)
		CYCc	899..1097	CDD:214485	60/208 (29%)
		Guanylate_cyc	928..1126	CDD:278633	62/198 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810