DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and si:ch211-132f19.7

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_688903.4	Gene:	si:ch211-132f19.7 / 560410	ZFINID:	ZDB-GENE-130530-619	Length:	1183	Species:	Danio rerio

Alignment Length:	518	Identity:	126/518 - (24%)
Similarity:	225/518 - (43%)	Gaps:	113/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 KEMHIE----LVREEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVF 218
            |:.|||    .:|:|:....:..:|.|..    |.:|:.|:....:..|:....|..:|.:.:|
Zfish   652 KDTHIEGKFSQMRDEMFKSNLACSFLLLL----FIMAAQALIPSPQFFPMIIQFLVFLFVYMLV- 711

  Fly   219 GADMVVRSIGNSLMVILPELLGKK------ITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPV 277
                        |:|.|.|...:.      :..|               ::.|.:|..|:|:..:
Zfish   712 ------------LLVTLAEEFKRSPPYLQHLCCW---------------IHETKSIRNLLTLTAI 749

  Fly   278 TERFDVQN----------EDLLQHEDGSEPEKS-----------LRLKGQMVYMENWRMIMFLGT 321
            ...|.|.:          |:..:....||..|.           ..|.| :|.|....:.:.|..
Zfish   750 AINFGVASCNIFWCNGTFEETEKSNKNSEHGKQWPVNICTHPEFFVLSG-VVAMVTCAVFLRLSC 813

  Fly   322 PV-MPDLTSLITTGLYINDLSMHD-FSRDLMLAGTQQSVELK----------LALDQEQQKSKKL 374
            .: :..||.:|....|:.:::.|. |.|....:..|:|..|:          :.:......|::|
Zfish   814 LLKLAVLTLVIAVYTYLIEVAFHVLFIRQHQNSQIQRSQYLRRKGISVLLMAMFVVVVLYNSRQL 878

  Fly   375 EESMRLLD--------------EEMRRTDE-LLYQMIPKQVADR-LRRGENPIDT-CEMFDSVSI 422
            |.:.| ||              :|:|..:| |||.::|..||.. |.|..|..|. .|.::.|.:
Zfish   879 ETTSR-LDFLWRLQARQEVEDMKELREHNECLLYNILPAHVARHFLERDRNNEDLFSESYERVGV 942

  Fly   423 LFSDIVTFTEICSR----ITPMEVVSMLNAMYSIFDKLTER---NSVYKVETIGDAYMVVAG-AP 479
            :|:.|..|::...:    ...:|.:.:||.:.:.||:|.:.   ..:.|::|||..||..:| :|
Zfish   943 MFASIPGFSDYYEKKELIHQDVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSP 1007

  Fly   480 DK-----DANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFG 539
            :|     :..|...:...||.|.:.:.:: :..|.....:|||:..|.||||::|...|:|.::|
Zfish  1008 EKQECEDEWAHLSTLVLFALAMQETLKEI-NKRTSNDFWLRVGISHGPVVAGVIGATKPQYDIWG 1071

  Fly   540 DTVNTASRMESTSIAMKVHISEST-KVLIGPNYKIIERGEIDVKG----KGTMGTYWLEEREN 597
            .|||.||||:||.::.::.:.|:| :||....:.:..||||.|||    :|.:.||::..||:
Zfish  1072 MTVNLASRMDSTGLSGRIQVPEATSRVLAEHGFMLQLRGEIYVKGVSERRGAVRTYFVSSREH 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	4/9 (44%)
		HNOBA	201..404	CDD:311573	49/257 (19%)
		CYCc	383..571	CDD:214485	63/204 (31%)
		Herpes_ICP4_C	794..>955	CDD:332854
si:ch211-132f19.7	XP_688903.4	AC_N	<133..375	CDD:292831
		CYCc	338..537	CDD:214485
		Guanylate_cyc	381..559	CDD:278633
		DUF1053	579..667	CDD:283888	5/14 (36%)
		CYCc	903..1103	CDD:214485	62/200 (31%)
		Guanylate_cyc	932..1131	CDD:278633	60/199 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810