DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and ADCY10

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	183	Identity:	46/183 - (25%)
Similarity:	80/183 - (43%)	Gaps:	39/183 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 DEEMRRT-DELLYQMIPKQVADRLRRGE----NPIDTCEMFDSVSILFSDIVTFTEICSRITP-- 439
            |.|:..: .:.:.:.|.||:.::..:|.    .|:..  :|  |:::|.|.....||...|..
Human   258 DPELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTI--VF--VNLMFEDQDKAEEIGPAIQDAY 318

  Fly   440 MEVVSML-------NAMYSIFDKLTERNSVYKVETIGDAYMVVAGAP-DKDANHAERVCDMALDM 496
            |.:.|:|       |.:: :|||             |.:::.|.|.| :|..:......:.|:|:
Human   319 MHITSVLKIFQGQINKVF-MFDK-------------GCSFLCVFGFPGEKVPDELTHALECAMDI 369

  Fly   497 VDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKM-PRYCLFGDTVNTASRM 548
            .|..:.:....|     :.:||.||.|..||||..: ..|.:.|..||.|:||
Human   370 FDFCSQVHKIQT-----VSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARM 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	5/22 (23%)
		CYCc	383..571	CDD:214485	45/182 (25%)
		Herpes_ICP4_C	794..>955	CDD:332854
ADCY10	NP_060887.2	CHD	40..214	CDD:143636
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	39/149 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900