DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and gucy1b2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	658	Identity:	234/658 - (35%)
Similarity:	359/658 - (54%)	Gaps:	83/658 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDF 65
            |||.:...|...:...:|||.||::|..||:.. :|..:::|.:.:..:|.::|.::|.||....
Zfish     1 MYGFINTCLKSLVIERFGEETWENLRLMAGVQE-TFMTYEIYDDIITLRLVQEACKMLDVSSEVV 64

  Fly    66 MDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLT 130
            :...|.||..|....|||.:|..||.::.:|:..||.||.||..||..|.||||..|......:.
Zfish    65 LKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEAMNAPSFRVERMDDGRIL 129

  Fly   131 LHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELV-----------REEILFDTVH---VT---F 178
            |||.|.|:|..:...|.|..||:.|:..|:.:.::           :|.::|..|.   ||   .
Zfish   130 LHYYSDRKGLYHIVPGIIEAVAKDFFDSEVTMTILNQSEEDERTGKKEHVVFHMVQKEKVTKRKA 194

  Fly   179 QLTFDNRAFTLASLAMTREE--------------------------------------------- 198
            |...:|....:..:...:||
Zfish   195 QTRQNNSEEEILEVKKDKEETMRRMKARYANLQLCPRKRSPWELVRSIVMLGQGNLRQSFTPSYP 259

  Fly   199 KHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPEL--LGKKITAWFDLVRPLIAFKFQTI 261
            |.|.|........|||.:||.:|:||:..|.::...:|.|  .|.::..:|.:|.|.:.|..|:|
Zfish   260 KTLWIEEQAFCNAFPFHIVFDSDLVVKHTGVNIQKFVPGLQTAGIRLDEYFTIVHPEVIFNIQSI 324

  Fly   262 LNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVMPD 326
            ....|:.|.|.|           ..::|.....::|  :|:|:|||::||:...:::|.:|.:..
Zfish   325 KKFINSQFVLKT-----------RREMLPEVQQNQP--TLKLRGQMMWMESLNCMIYLCSPKLRS 376

  Fly   327 LTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTDEL 391
            |..|...||::.|::.||.:|||:|...|:..|::|: :|.::|.::|....|.|:.|.:::::|
Zfish   377 LQELEERGLHLADIAQHDTTRDLILLNQQRLAEIELS-NQLERKKEELRILSRNLEIEKQKSEKL 440

  Fly   392 LYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKL 456
            ||.|:|..||::|:.|:. ::..| |...:|||||:||||.||:...|:::|:|||||||.||:|
Zfish   441 LYAMLPTHVANQLKEGKR-VEAGE-FKVCTILFSDVVTFTNICAACEPIQIVNMLNAMYSRFDRL 503

  Fly   457 TERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSG 521
            |..::||||||||||||||.|.|.....|||||.:.||.|..|..::.:|.|||.::||||:|:|
Zfish   504 TSIHNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGMRIAAREVTNPITGQPIQIRVGLHTG 568

  Fly   522 AVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPN--YKIIERGEIDVKGK 584
            .|:||:||.||||||||||||||||||||..:...:|:|..|..:|...  :::.|||||:||||
Zfish   569 PVLAGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFEMAERGEIEVKGK 633

  Fly   585 GTMGTYWL 592
            |.|.||:|
Zfish   634 GLMRTYFL 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	55/161 (34%)
		HNOBA	201..404	CDD:311573	62/204 (30%)
		CYCc	383..571	CDD:214485	100/189 (53%)
		Herpes_ICP4_C	794..>955	CDD:332854
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	55/161 (34%)
		CAF-1_p150	<166..277	CDD:288454	15/110 (14%)
		HNOBA	269..453	CDD:285003	60/197 (30%)
		CYCc	432..618	CDD:214485	100/187 (53%)
		Guanylate_cyc	459..642	CDD:278633	104/184 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2977
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5317
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.810