DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and gucy1a1

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001296458.1	Gene:	gucy1a1 / 550420	ZFINID:	ZDB-GENE-050417-230	Length:	679	Species:	Danio rerio

Alignment Length:	529	Identity:	181/529 - (34%)
Similarity:	274/529 - (51%)	Gaps:	67/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VLSVLGRHMRDFLNGLDNLHEYLKFSYP-------RMRAPSFICENETKQGLTLHYRSKRRGFVY 142
            :|.|:|..:.||||..:.|   ||.|.|       .:...|.:|.::....||:::.:.......
Zfish   153 ILRVVGGALHDFLNSFNVL---LKQSTPPTPEIQRYIHQASILCLDKDPGLLTVYFFNPLPSTEL 214

  Fly   143 YTMGQIREVARYFYHKEMHIELVREEILFDT-------------VHVTFQLTF-DNRAFTLASLA 193
            :..|.|:..|...|       ..|.|:..|.             .|:.:.:.. |.|:.| .|..
Zfish   215 FFSGIIQAAACLLY-------CTRVEVRMDVGGKDSGALQADHQPHLLYSVVVRDGRSLT-PSPM 271

  Fly   194 MTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELL-GKKITAW---FDLVRPLI 254
            .|.....:|:|  :|:..|||.::...:|.:..||:.|...|.... |::..|:   |.:|.|.|
Zfish   272 RTHTSGDIPLS--LLYSTFPFHILLDQEMGLLQIGDGLRRRLGRCRDGQRRPAFNEHFAIVSPEI 334

  Fly   255 AFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQH--EDGSEPEKSLRLKGQMVYMENWRMIM 317
            ...||.||...|..|.|               .:.||  .....|.|.:.|||||::|.....::
Zfish   335 RASFQDILTMLNTQFLL---------------RVKQHGASSADSPGKHMDLKGQMIFMSEMSALL 384

  Fly   318 FLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE--LKLALDQEQQKSK-KLEESMR 379
            |||:|.:..|..|...|||::|:.:|:..||::|.|.|...:  ||..|.    |:| .||::.:
Zfish   385 FLGSPCVDKLEELTGRGLYLSDIPIHNALRDVVLVGEQTKAQDGLKKRLG----KAKAALEQAHQ 445

  Fly   380 LLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVS 444
            .|:||.|||.|||:.:.|..||.||.:| .|:. .:.||.|::||||||.||.||||.|||:||:
Zfish   446 ALEEEKRRTVELLFTIFPGNVAQRLWQG-LPVQ-AKKFDHVTVLFSDIVGFTAICSRCTPMQVVN 508

  Fly   445 MLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTG 509
            ||:.:|:.||.......|||||||||||.|..|...:...||.::..|||.|::...::..| .|
Zfish   509 MLSELYTRFDHHCGELDVYKVETIGDAYCVAGGLHKESPTHAVQIALMALKMMELSDEVTTP-MG 572

  Fly   510 QHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIG--PNYK 572
            :.:|:|:|:|||:|:||:||:|||||||||:.|..|::.||.|:..|:::|.:|..|:.  |.:.
Zfish   573 EVIRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFESCSLPRKINVSPTTYRLLKDCPEFT 637

  Fly   573 IIERGEIDV 581
            :|.|...|:
Zfish   638 LIPRTREDL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	20/85 (24%)
		HNOBA	201..404	CDD:311573	69/211 (33%)
		CYCc	383..571	CDD:214485	91/189 (48%)
		Herpes_ICP4_C	794..>955	CDD:332854
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	69/211 (33%)
		CYCc	449..635	CDD:214485	90/188 (48%)
		Guanylate_cyc	476..647	CDD:278633	79/173 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820