DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Adcy4

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_062158.2	Gene:	Adcy4 / 54223	RGDID:	2034	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	103/383 - (26%)
Similarity:	183/383 - (47%)	Gaps:	64/383 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 VMPDLTSLITTGLYINDLSMHDFSRDLM--------------LAGTQQSVELKLALDQEQQKSKK 373
            |:..|:.|:..|||:.  ...:..|||:              :.|......::.||....:::..
  Rat   146 VISSLSHLLVLGLYLG--WRPESQRDLLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALS 208

  Fly   374 LEESMRLLDEEMRRTDELLYQMIP--------KQVADRLRRGEN--PIDT-------CEMFDSVS 421
            ...|.|.||.|.:..:.||..::|        .::..||:.|::  |.:|       .:....||
  Rat   209 SLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSSRPENTNNFHSLYVKRHQGVS 273

  Fly   422 ILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHA 486
            :|::|||.||.:.|..:|.|:|.|||.::..||::.:.:...:::.:||.|..|:|.|....:||
  Rat   274 VLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHA 338

  Fly   487 ERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMEST 551
            .....|.|||..||..|: .:||..:.:|||||||:|:.|::||:..:|.::...|..|:.||:.
  Rat   339 INCVRMGLDMCRAIRKLR-VATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAG 402

  Fly   552 SIAMKVHISESTKVLIGPNYKIIERGEIDVKGK--GTMG--TY-----WLEERENR-LPLQLTAA 606
            .:..:|||:.:|..|:...| .:||.:::.:..  ..:|  ||     |.||.:.: ....|.::
  Rat   403 GVPGRVHITGATLALLAGAY-AVERADMEHRDPYLRELGEPTYLVIDPWAEEEDEKGTERGLLSS 466

  Fly   607 LQVHPLSPVPPTPTPKTKAIMPPVSKPLTPMMPVSVSLAASMPTSNVPAVDVMASSSS 664
            |:.|.:.|                |..:|..:.   |..|:.|.:::..||..||:|:
  Rat   467 LEGHTMRP----------------SLLMTRYLE---SWGAAKPFAHLSHVDSPASTST 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	20/102 (20%)
		CYCc	383..571	CDD:214485	64/204 (31%)
		Herpes_ICP4_C	794..>955	CDD:332854
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831	20/101 (20%)
		CYCc	219..422	CDD:214485	64/203 (32%)
		Guanylate_cyc	264..430	CDD:278633	58/167 (35%)
		DUF1053	479..580	CDD:283888	9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..523		4/8 (50%)
		CYCc	824..1039	CDD:214485
		Guanylate_cyc	861..1060	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810