DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	1150	Identity:	209/1150 - (18%)
Similarity:	347/1150 - (30%)	Gaps:	446/1150 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YGLLLENLSEYIKSVYGEEKWEDIRRQAG---------IDSPSFSVHQVYPENLLQKLAKKAQQV 57
            |.:..|.|:||       ::|:   |||.         :|...:|:.:| ||:|.
  Rat   262 YHVSFETLAEY-------QRWQ---RQASKVVSQRISTVDLSCYSLEEV-PEHLF---------- 305

  Fly    58 LGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLG-RHMRDFL-----NGLDNLHEY-----LKFSY 111
                                    |.:.::.|. ||  :|:     .|||.|:::     |..|:
  Rat   306 ------------------------YSQDITYLNLRH--NFMQLERPGGLDTLYKFSQLKGLNLSH 344

  Fly   112 PRMRA-PSFICENETKQGLTLH-------------------------------------YRSKRR 138
            .::.. |..:||..|...|.|.                                     .:....
  Rat   345 NKLGLFPVLLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNVLTALPDELGNLQQLTSL 409

  Fly   139 GFVYYTMGQIREV---------------------------ARYFYHKEM---HIELVREEILFDT 173
            |..:....||.||                           ..:..|.::   |::.|..|.|...
  Rat   410 GISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGN 474

  Fly   174 VHVTFQLTFDNRA--FTLASLAMTREEKH--------LPISAHVLFEIF------PFCMVFGADM 222
            .|:|.....||:.  ..|:||. :.|:.|        |.:|...|..::      ....|:....
  Rat   475 KHITHMDLRDNQLTDLDLSSLC-SLEQLHCERNQLRELTLSGFSLRNLYANWNKLTAVNVYPVPS 538

  Fly   223 VVRS--IGNSLMVILPELL--GKKITAWFDL---------VRPLIAFKFQTILNRTNNIFEL-VT 273
            ::.|  :..:|:..:|:..  .||:.. .|:         :|.|.:...:.::...|:|..| ..
  Rat   539 LLTSLELSRNLLECIPDWACEAKKLEI-LDISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPAL 602

  Fly   274 VDPV-TERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYM-----------------ENWRMIMFLG 320
            |:.: .|..|||:..|.:..| :...|:|.|:    |:                 |:..::..|
  Rat   603 VEHIPLEVLDVQHNTLSRLPD-TLFSKALNLR----YLNASANSLESLPSACAGEESLSVLQLL- 661

  Fly   321 TPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEM 385
                 .||:.:.|...|..|..|...|.|.||..|...       ....|..|||:.     ||:
  Rat   662 -----YLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQT-------FPASKLNKLEQL-----EEL 709

  Fly   386 RRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEI------------CSRIT 438
            ..:...| :.||..:|:           |:...::....::|..|.||            |:.:|
  Rat   710 NLSGNKL-KAIPTTIAN-----------CKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLT 762

  Fly   439 PMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDL 503
            .:.:...|.|.....|.....|.|.:.:|                          |||...||.|
  Rat   763 EILIPETLPATLQDLDLTGNTNLVLEHKT--------------------------LDMFSHITTL 801

  Fly   504 KD-----PSTGQHLRIRVGVHSGAVVAG------IVGLKMPR--------YCLF-GDTVNTASRM 548
            |.     |:|...:......|..|.:||      :..|.|..        |.:| ||......|:
  Rat   802 KIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYGMFDGDRNEELPRL 866

  Fly   549 ESTSIA----MKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWL------EERENRLPLQL 603
            ...::|    .:|..|.|..|.:...:.:..| ::.:.|: .:|:..|      :..:......|
  Rat   867 LQCTMADVLLEEVQHSTSDTVFMANTFLVSHR-KLGMAGQ-KLGSSALLCYIRPDTADPTSSFSL 929

  Fly   604 TAALQVHPLSPV-----PPTPTPKT----------------KAIMPP------------------ 629
            |.| .|.....|     .|.|..|.                |||:..
  Rat   930 TVA-NVGTCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTY 993

  Fly   630 -----VSKPLTPMMPVSVS-----------------LAASMPTSNVPAVDVMASSSSISGLALT- 671
                 :.||.....|:::.                 |.|.....:|.  |.:|::..:..||.:
  Rat   994 LYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQ--DPLAAAKKLCTLAQSY 1056

  Fly   672 ------AAAAAHMSLHHQAVVAE------------ALTGASVEVALPSVASGATGAAAGGGAPSD 718
                  .|...::::..:....|            |.|....:...|:..|.::|.|
  Rat  1057 GCQDNVGAMVVYLNIGEEGCTCEMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIA-------- 1113

  Fly   719 DRNSRIYSPVTFKDVARRSVANSPVRSCAQ-------------PDQERRRESRSNSTGHVFMRTP 770
               |.:.|.|:..:|      :|.|.|.|.             |..|||.......:...|.|.|
  Rat  1114 ---SELSSEVSTSEV------SSEVGSTASDEHNTVGLETSLLPRPERRCSLHPVPSAGTFQRQP 1169

  Fly   771 S-EIFGS------LILDTEEFLE-------------DLQISRSSLANNN-----NNQSPC----- 805
            | ..|.|      |..|.::.:|             |:...|...:.|:     |:..||
  Rat  1170 SCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGRESENSPTLPKNSSYPCSEEHA 1234

  Fly   806 ---GFSPTPPFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPPSTA 847
               ||.......:.|.  ...|.|.||        |:....|||:
  Rat  1235 RGLGFGIRRQNSVNSG--ILLPVNKDK--------MELQKSPSTS 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	39/249 (16%)
		HNOBA	201..404	CDD:311573	49/240 (20%)
		CYCc	383..571	CDD:214485	44/223 (20%)
		Herpes_ICP4_C	794..>955	CDD:332854	15/66 (23%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131	7/26 (27%)
		PLN00113	284..>762	CDD:215061	97/551 (18%)
		leucine-rich repeat	289..309	CDD:275380	7/54 (13%)
		leucine-rich repeat	310..336	CDD:275380	8/27 (30%)
		leucine-rich repeat	337..359	CDD:275380	5/21 (24%)
		leucine-rich repeat	360..382	CDD:275380	2/21 (10%)
		leucine-rich repeat	383..405	CDD:275380	0/21 (0%)
		leucine-rich repeat	406..428	CDD:275380	5/21 (24%)
		leucine-rich repeat	429..452	CDD:275380	0/22 (0%)
		leucine-rich repeat	453..476	CDD:275380	5/22 (23%)
		leucine-rich repeat	477..497	CDD:275380	6/20 (30%)
		leucine-rich repeat	498..517	CDD:275380	4/18 (22%)
		leucine-rich repeat	518..539	CDD:275380	2/20 (10%)
		leucine-rich repeat	540..562	CDD:275380	3/21 (14%)
		leucine-rich repeat	563..584	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..607	CDD:275380	4/20 (20%)
		leucine-rich repeat	608..631	CDD:275380	7/23 (30%)
		leucine-rich repeat	632..681	CDD:275380	10/58 (17%)
		leucine-rich repeat	682..705	CDD:275380	8/29 (28%)
		leucine-rich repeat	706..728	CDD:275380	7/38 (18%)
		leucine-rich repeat	751..772	CDD:275380	3/20 (15%)
		PP2Cc	820..1069	CDD:238083	42/253 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900