DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and Gycbeta100B

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	860	Identity:	242/860 - (28%)
Similarity:	381/860 - (44%)	Gaps:	222/860 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGID-SPSFSVHQVYPENLLQKLAKKAQQVLGVSERD 64
            |||.:...|...:...:|||.||.|:::|.:. ...|.|.|:|.:.:...|...|.::|.:...|
  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65

  Fly    65 FMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQG- 128
            .::..|..|..|....|||::|.|||...||||..||.||::|...||.||||||.|..  |.|
  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCTE--KDGE 128

  Fly   129 LTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVR-------------------EEILFDTV 174
            |.|||.|:|.|..:..:|.::.||...:..|:.|::|:                   :::|.|.|
  Fly   129 LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193

  Fly   175 HVTFQLTFDNRAFTLA----------------------------------------------SLA 193
            ..|   |..:....||                                              |:|
  Fly   194 ATT---TTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIA 255

  Fly   194 MT--------------REEKHLPISA----------HVLF------------------------- 209
            ::              :|:|.|.:..          ||.|
  Fly   256 LSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDME 320

  Fly   210 --------------EIFPFCMVFGADMVVRSIGNSLMVILPELLGK--KITAWFDLVRPLIAFKF 258
                          ::|||.::|...|.:...|.::..::|.:..:  .:....:.:||.:...|
  Fly   321 FLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNF 385

  Fly   259 QTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPV 323
            :.||:..|.|:.|.|         .|.....:||     ::.|||||||:|:.....|:|...|.
  Fly   386 ENILSHINTIYVLQT---------RQGAMSSRHE-----QRFLRLKGQMMYIPETDRILFQCYPS 436

  Fly   324 MPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRT 388
            :.:|..|...||||:|:.:||.:|||:|...:...|.||..:.| ..:.||:::.|.|:.|.::|
  Fly   437 VMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLE-MLTDKLQQTFRDLESEKQKT 500

  Fly   389 DELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRIT----PMEVVSMLNAM 449
            |.|||.::||.||:.||. :.|:.. :.:|||:::||.||.|.:.|:..|    .|::|.|||.:
  Fly   501 DRLLYSVLPKSVANELRH-QRPVPP-KRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNEL 563

  Fly   450 YSIFDKLTE--RN-SVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQH 511
            |::||.||:  || :||||||:||.||.|:|.||...:||:.:..:||||:|...::|..|  ..
  Fly   564 YTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGS--NP 626

  Fly   512 LRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLI------GPN 570
            ::|.:|:|||.||.|::|.::|||||||:|||..||.|:|.:..::::||.|..|:      ..:
  Fly   627 VQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDS 691

  Fly   571 YKIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAALQVHPLSPVPPTPTPKTKAIMPPVSKPLT 635
            :.:..||.:.:|||.|....|...|.....|..|        |....:......::..|:.:|.|
  Fly   692 FHLEYRGPVIMKGKPTPMDCWFLTRATSSILGGT--------SSTGGSGGGGNGSLDSPLLQPAT 748

  Fly   636 PMMPVSVSLAASMPTSNVPAVDVMASSSSISGLALTAAAAAHMSLHHQAVVAEALTGASVEVALP 700
            |                                  ||.||..:     .|||:...|.:
  Fly   749 P----------------------------------TAGAATPI-----PVVAQRAAGHA------ 768

  Fly   701 SVASGATGAAAGGGA 715
            ||:..::....||||
  Fly   769 SVSRTSSAGGGGGGA 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	60/163 (37%)
		HNOBA	201..404	CDD:311573	65/253 (26%)
		CYCc	383..571	CDD:214485	85/200 (43%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	60/163 (37%)
		HNOBA	326..516	CDD:285003	61/204 (30%)
		CYCc	496..688	CDD:214485	85/195 (44%)
		Guanylate_cyc	522..714	CDD:278633	79/194 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24411at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5317
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.880