DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and Gyc89Da

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	233/676 - (34%)
Similarity:	355/676 - (52%)	Gaps:	95/676 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDF 65
            |||:|.|::..|::..||.:.|..:.........||..||:||:.|:..:|:......|.|....
  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGESFDFC 65

  Fly    66 MDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLT 130
            |:..|..||.|...:|||:::...||:..|||..:||:|..::|:||:|::||....|....|..
  Fly    66 MNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAV 130

  Fly   131 LHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREE-----------ILFD---TVHVTFQLT 181
            :.|||.|.|...|.:||:.||||.||..|:...::..:           .|.|   ||.|.::|.
  Fly   131 ILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLD 195

  Fly   182 FDNRAFTLASLAMTREEKH-----LP-ISAHVLFEIFPFCMVFGADMVVRSIGNSLMVIL----- 235
            ||||.: :|....|  |.|     :| :...|..::|||..|...||.:...|..::...
  Fly   196 FDNREY-MAKRVNT--EAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNP 257

  Fly   236 ----PELLGKKITAWFDLVRP--------------LIAFKFQTIL---NRT------NNIFE--- 270
                ...:|..:...|...||              .:.|:|:.|.   ||.      |..||
  Fly   258 GANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYD 322

  Fly   271 -----------LVTVDPVTERFDVQNEDLLQHED---------GSEPEKSLRLKGQMVYMENWRM 315
                       |......:|...|.:::..:.::         .|:..:|:.|||||.|:::...
  Fly   323 EMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDS 387

  Fly   316 IMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRL 380
            ::||.:|::.:|..|...|||:|||:.|..||:|::||.|...:|::..::|:|:|.:||:|:.|
  Fly   388 LIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLEL 452

  Fly   381 LDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIV-TFTEICSRIT-PMEVV 443
            .|...|:.|||||.|||:.:|:|:|..|..:  |:.|:.||::|.::: .:.|..:.|. .|:.|
  Fly   453 ADSWKRQGDELLYSMIPRPIAERMRLSEEQV--CQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTV 515

  Fly   444 SMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAIT--DLKDP 506
            :.||.::|..|:......||||||:|..||.|:||||.:..|||..||:||.::....  |:.|
  Fly   516 NTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKFKAHDMGD- 579

  Fly   507 STGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST--KV-LIG 568
                 :.||||::||.||||:||.|:||||||||||||||||||:|...|:.:|:.|  || .:|
  Fly   580 -----VAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVG 639

  Fly   569 PNYKIIERGEIDVKGKGTMGTYWLEE 594
              ||:..||.:.|||||.|.||||.|
  Fly   640 --YKVESRGTVQVKGKGDMETYWLLE 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	57/161 (35%)
		HNOBA	201..404	CDD:311573	69/258 (27%)
		CYCc	383..571	CDD:214485	87/194 (45%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	57/158 (36%)
		HNOBA	218..476	CDD:285003	69/257 (27%)
		CYCc	457..643	CDD:214485	89/195 (46%)
		Guanylate_cyc	485..662	CDD:278633	86/184 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14750at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850