DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and ACXC

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	121/523 - (23%)
Similarity:	210/523 - (40%)	Gaps:	124/523 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LDNLHEYL-KFSYPRMRAPSFICENETK--------QGLTLHYRSKRRGFVYYTMGQIREVARYF 155
            ||..:|.| :.||.|.:......|.|.:        ..||:.|..    |:...|..:.....|.
  Fly    23 LDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVL----FIILAMSFLTIELLYV 83

  Fly   156 YHK-----EMHIELVREEILFDTVHVTFQLTFDNR------AFTLASLAMTREEKHLPISAH--- 206
            .|.     ...|.:|...::...:.:.|...|.:|      |.::.|:.:......:.||.|
  Fly    84 QHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYK 148

  Fly   207 ------VLFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITA-WFDLVRPLIAFKFQTILNR 264
                  ..|::|..||::            :.:.:|.:.|..:.| ...|:  .:||...::
  Fly   149 NDWPLNTSFDVFTLCMIY------------MFLPIPSIKGAALLASSVSLI--YVAFFMHSL--- 196

  Fly   265 TNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTS 329
               .|..|..|..:..:||.:.|:| |..|.                |...|.|   .:|.|
  Fly   197 ---TFNAVYTDRDSFGYDVISTDIL-HNLGF----------------NMMGIFF---RIMND--- 235

  Fly   330 LITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQ 394
               |.:..:.|..|.|        ..:...|:.||         |:||:.|        |.:|..
  Fly   236 ---TMVRASFLDRHQF--------IMEETWLRHAL---------LQESILL--------DSILPP 272

  Fly   395 MIPKQVADRLR----RGENPID-------TCEMF------DSVSILFSDIVTFTEICSRITPMEV 442
            .|.|.|.::::    :.||..|       |.|.|      ..||||::|:|.:|.:.:.:|...:
  Fly   273 QIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNL 337

  Fly   443 VSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPS 507
            |.:|:.:|..||.......|.:::.:||.|..|||....|.:||:....:.:.|:..|.::: ..
  Fly   338 VKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVR-AE 401

  Fly   508 TGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGP-NY 571
            .|..:.:|:|||||:::|||:|....::.::|..|..|:.:|||.....||:|..|..::.| :|
  Fly   402 RGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADY 466

  Fly   572 KII 574
            .|:
  Fly   467 TIL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	17/77 (22%)
		HNOBA	201..404	CDD:311573	43/212 (20%)
		CYCc	383..571	CDD:214485	58/205 (28%)
		Herpes_ICP4_C	794..>955	CDD:332854
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	62/326 (19%)
		CYCc	293..468	CDD:214485	52/175 (30%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	47/159 (30%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740