DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Ac13E

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	195/847 - (23%)
Similarity:	310/847 - (36%)	Gaps:	210/847 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 GTPVMPDLTSLITTGLYINDLSMHDFSRDLM-LAGTQQSVELKLALDQEQQKSKKLEESMRLLDE 383
            |.|....|...|...|.::.:.:|....:|: :.||...|...|.:.::.:..|:|:|.|
  Fly   251 GDPSNRILILRIMAHLSVHLVGVHVLIMNLVRMRGTFMKVGQNLLVRRQLEMEKQLKEKM----- 310

  Fly   384 EMRRTDELLYQMIPKQVADRLRRGENPI--------------------DTCEMF--------DSV 420
                    ::.::|.:|||.|.....|.                    |...:|        ::|
  Fly   311 --------IHSVMPPKVADMLLNEGGPSGLDAGGLPPESHYMRPRASNDVKSLFRPFHMHSMENV 367

  Fly   421 SILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANH 485
            ||||:|||.||.:.|..|..::|.:||.::..||.|...:...|:.|:||.|..|:|.|:..|:|
  Fly   368 SILFADIVGFTRMSSTKTAEQLVEILNDLFERFDDLCSLSGCEKISTLGDCYYCVSGCPEPRADH 432

  Fly   486 AERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMES 550
            |....:|.|.|:||:... |....:.:::|||||:|.|:.||||.:..::.::.:.|:.|::|||
  Fly   433 AICCVEMGLGMIDAMRCF-DAQRHEGVKMRVGVHTGTVLCGIVGTRRVKFDVWSNDVSLANKMES 496

  Fly   551 TSIAMKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEEREN----------RLPLQLT- 604
            :....:||||:.|...:|..| .:|.|| :|.|.   .||::..|..          .:|...|
  Fly   497 SGKPEQVHISQETSSFLGDAY-YLEEGE-EVFGH---RTYFVVGRRRDFTRTNSLSPSMPANATG 556

  Fly   605 ---------------AALQVHPLSP-VPP-TPTPKTKAIMPPVSKPLTPMMPVSVSLAASM---- 648
                           :|..|..:.| ||| :|..:..:.:.|  .|:..|.|...||:..|
  Fly   557 SSLLLPGAHGASLSQSATNVSAVQPNVPPASPVGQLSSSLNP--SPVLSMRPRLTSLSMKMRKKS 619

  Fly   649 --------------PTSNVPAVDVMASSSSISGLALTAAAAAHMSLHHQAVVAEALTGASVEVAL 699
                          ..:.:|.|.|:.....|  :..|.:....:....|..|:..|        |
  Fly   620 QSRDRDVERGIIHPAAAGIPPVIVVRERPKI--IITTKSLPGSLDSDEQPPVSPPL--------L 674

  Fly   700 PSVASGATGAAAGGGAPSDDRNSRIYSPV--------TFKDVARRSVANSPVRSCAQPDQERRRE 756
            |.           ...|:.:..|:|...|        .|:|:..||..... .|....|:||.||
  Fly   675 PP-----------ANPPAAETRSKIKLKVWKIPRFLKRFEDLTNRSSCGGS-SSAGHLDKERERE 727

  Fly   757 SRSNSTGHVFMRTPSEIFGSLILDTEEFLEDLQISRSSLANNNNNQSPCGFSPTPPF-----RIG 816
            ..         :...|:.....|:.||.|       :.:.|...|.:.||:...|..     |..
  Fly   728 RE---------KEKEELHQHNQLNPEETL-------AFMDNQMQNGNGCGYQQLPVLVESNHRTQ 776

  Fly   817 SAP-PKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSA--SLDRDKATKLKKITFSNS-- 876
            :.. |..||......|...||: ..|..|....:.....||..  |:..|.......|:.|.|
  Fly   777 TLDIPAARPVLHHAATSTALAS-SVLRSPEAGVSGGGGCCSPGQYSMYDDIIDVRSYISQSRSDI 840

  Fly   877 ---------------SSLDATTPTALAAVVCPMRT----KSPPMAVAPVMHMVQASTSKGDGQRP 922
                           .|.........|.|....|.    .:||:..:| :...:|||.......|
  Fly   841 SPFGRSGSYRSQCGRQSTGGVNGAGPAGVGAEGRAGTSQTAPPVEQSP-LPRPRASTLATGRPTP 904

  Fly   923 GSKD----SVSSISLHSP----------PPHRSN------SAPARPHSMSKAARKAFLAAKQTKA 967
            .|.:    |.|...|.:|          ||..|.      ||.:|..|..|:..:.....:|..|
  Fly   905 NSLEPGPSSTSPCCLPAPGNSVGGGGIFPPTHSRQSSICPSATSRKDSGIKSNSRRSSIQQQIYA 969

  Fly   968 MEKLDKMIEEVQEVESQSVAKAANMRLALYGHDGGGDLAAGGCPLFLPPPPQQQQQQQQSLMPSS 1032
            :.:.......|....:.|.:..:|:          |::...|.||.:.|||       ..|||:.
  Fly   970 LNQTAISQHRVSGYFTSSTSSISNL----------GEVQGLGLPLAVQPPP-------PLLMPAC 1017

  Fly  1033 IS 1034
            .|
  Fly  1018 SS 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	19/84 (23%)
		CYCc	383..571	CDD:214485	65/215 (30%)
		Herpes_ICP4_C	794..>955	CDD:332854	45/209 (22%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485	70/230 (30%)
		Guanylate_cyc	361..535	CDD:278633	65/179 (36%)
		CYCc	1362..1556	CDD:214485
		Guanylate_cyc	1388..1575	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740