DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and rut

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_511156.2	Gene:	rut / 32406	FlyBaseID:	FBgn0003301	Length:	2248	Species:	Drosophila melanogaster

Alignment Length:	1067	Identity:	208/1067 - (19%)
Similarity:	370/1067 - (34%)	Gaps:	338/1067 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 VHVTFQLTFDNRA-------------FTLASLAM---TREEKHLPISAHVLFEIFPFCMVFGADM 222
            |.....|||:|.|             |.:..:.:   ..::.|||...:.:       ::|.|.:
  Fly    52 VMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGI-------LLFTASI 109

  Fly   223 VVRS---IGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQ 284
            .|.|   :|:...|...|::.:.:  |..:....:|:....:     .|:|.|.       |.:
  Fly   110 CVVSMPTLGSVFPVDTKEVMAEGV--WQIVFVVFLAYAMMPL-----QIWEAVA-------FGI- 159

  Fly   285 NEDLLQHEDGSEPEKSLRLKGQMVYMENWR----------MIMFLGTPVMPDLTSLITTGLYIND 339
                      :.|...:.|....::.:..|          :::|:|..|         .||.:|
  Fly   160 ----------ALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNV---------AGLVVN- 204

  Fly   340 LSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRL 404
                     :|:...|:    :..||.....:.:||     :.:|..:.:.||..::|:.||.::
  Fly   205 ---------IMMERAQR----RTFLDTRNCIASRLE-----IQDENEKLERLLLSVLPQHVAMQM 251

  Fly   405 RR-------GENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSV 462
            :.       |:......:..::|||||:|||.||.:.|:.:..|:|.:||.::..||:|...|..
  Fly   252 KNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHC 316

  Fly   463 YKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGI 527
            .:::.:||.|..|:|.|:...:||:...:|.|||:|||..:.: :|...|.:|||:|:|.|:.|:
  Fly   317 LRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVE-ATDVILNMRVGIHTGRVLCGV 380

  Fly   528 VGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWL 592
            :||:..::.::.:.|..|:.|||.....:||::.:|...:...|: :|.|..|
  Fly   381 LGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYE-VEAGHGD------------ 432

  Fly   593 EERENRLPLQLTAALQVHPLSP---VPPTPTPKTKAIMPPVSKPLTPMMPVSVSLAASMPTSNVP 654
             ||        ::.|:.|.:..   |||          |...|||.                 :.
  Fly   433 -ER--------SSYLRDHGVDTFFIVPP----------PHRRKPLM-----------------LN 461

  Fly   655 AVDVMASSSSISGLALTAAAAAHMSLHHQAVVAEALTGASVEV-ALPSVAS--------GATGAA 710
            .:.|.::..|...|:....:...|.|.|....:|.:..:::.. :.||.||        |..|..
  Fly   462 TLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGG 526

  Fly   711 AGGGAPSDDRNSRIYSPVTFKDVARRSVANSPVRSCAQPDQERRRESRSNSTGHVFMRTP----- 770
            .|||                  |||.|...:...:....::..|:..|.....|.   ||
  Fly   527 GGGG------------------VARGSTCEANSGNVQVSEKGSRKVIRLQKILHA---TPPPHGM 570

  Fly   771 --SEIFGS--------------------------LILDTEEFLEDLQISRSSLAN--NNNNQSPC 805
              ..:.||                          :.:.|........|||....|  ||.:||..
  Fly   571 GYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKV 635

  Fly   806 GFSPTPPFR-IGSAPPKPRPSN-PDKFTPEELAAMDQLTPPSTAPARETASCSSASLDRDKATKL 868
            ......||| ..|.....:|:| .::|..:.:                    ::.|:|.||:..:
  Fly   636 ADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAI--------------------NARSVDCDKSEHV 680

  Fly   869 KKIT-----------FSNSSSLDATTP------------------------------------TA 886
            .::|           :.....|..||.                                    :|
  Fly   681 DRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSA 745

  Fly   887 LAAVVCPMRTK----------SPPMAV-------------APVMHMVQASTSKGDGQRPGSKDSV 928
            :..::..:|.|          |..||:             ..|...|......|:|......||.
  Fly   746 ILMLLLAVRLKWIIWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSH 810

  Fly   929 SSISLHSPPPHRSNSAPARPHSMSKAAR-----------------KAFLAAKQTKAMEKLDKMIE 976
            ...||   |.:.|.||.....|:|...|                 ..|:........|..|..:.
  Fly   811 RKCSL---PQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVN 872

  Fly   977 EVQEVESQSVAKAANMRLALYGHDGGGDLAAGGCPL-FLPPPPQQQQQQQQSLMPSS---ISDSG 1037
            ....:...|:|:.|...:|:..|   |.|..|...| ||......|::::..::..|   |..:.
  Fly   873 ASIPLHLISLARIAIFMIAILVH---GRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNL 934

  Fly  1038 LCSHGHSHAPSCHHMDPKMTNSQSFQH 1064
            |.:|     .:.|.:|.:..|:....|
  Fly   935 LPAH-----VAAHFLDAQFRNNMELYH 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	36/215 (17%)
		CYCc	383..571	CDD:214485	60/194 (31%)
		Herpes_ICP4_C	794..>955	CDD:332854	40/234 (17%)
rut	NP_511156.2	AC_N	<17..255	CDD:292831	44/262 (17%)
		CYCc	230..425	CDD:214485	60/195 (31%)
		Guanylate_cyc	266..438	CDD:278633	59/194 (30%)
		DUF1053	624..696	CDD:283888	17/91 (19%)
		SLC5-6-like_sbd	<742..>893	CDD:294310	28/153 (18%)
		CYCc	924..1134	CDD:214485	8/38 (21%)
		Guanylate_cyc	954..1151	CDD:278633	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810