Protein Alignment Gyc88E and GUCY2D

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_000171.1
• Gene: GUCY2D / 3000
• HGNCID: 4689
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 182/680 - (26%)
• Similarity: 294/680 - (43%)
• Gaps: 173/680 - (25%)

  Fly    14 KSVYGEEKWEDIRR--QAGIDSPSFSVHQ-------VYPENLLQKLAKKAQQVLGVSERDFM--D 67
            :|..|.....|||.  ...:|||:..|::       .:|.:  |.:|.:.......|:...:  :
Human   528 RSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGD--QHIAIRPATKTAFSKLQELRHE 590

  Fly    68 QMGVYFVGFV--GQYG----YDRVLSVLGRH-------------------------MRDFLNGLD 101
            .:.:|...|:  |..|    ::..|:|:..|                         :.|.:.|:.
Human   591 NVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIR 655

  Fly   102 NLHEYLKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVR 166
            .|| :...::.|:::.:.|.:......:|.|    ..|.:......:.|..|.........||:|
Human   656 YLH-HRGVAHGRLKSRNCIVDGRFVLKITDH----GHGRLLEAQKVLPEPPRAEDQLWTAPELLR 715

  Fly   167 EEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSL 231
            :..|             .|..|||.                  ::|...::. .::|.||...::
Human   716 DPAL-------------ERRGTLAG------------------DVFSLAIIM-QEVVCRSAPYAM 748

  Fly   232 MVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSE 296
            :.:.||.:.:::.:...|.|||::.                      ::..|:...|::.....:
Human   749 LELTPEEVVQRVRSPPPLCRPLVSM----------------------DQAPVECILLMKQCWAEQ 791

  Fly   297 PEKSLRLKGQMVYMENWRMIMFLGTPVMP---DLTSLITTGLYINDLSMHDFSRDLMLAGTQQSV 358
            ||  ||                   |.|.   ||...|..|...|.:       |.||.
Human   792 PE--LR-------------------PSMDHTFDLFKNINKGRKTNII-------DSMLR------ 822

  Fly   359 ELKLALDQEQQKSKKLEESMRLLDEEM----RRTDELLYQMIPKQVADRLRRGENPIDTCEMFDS 419
                   ..:|.|..||:.:|...||:    ::||.||.||:|..||:.|:.| .|::. |.|:.
Human   823 -------MLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTG-TPVEP-EYFEQ 878

  Fly   420 VSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDA- 483
            |::.|||||.||.|.:...|:|||.:||.:|::||.:...:.|||||||||||||.:|.|.::.
Human   879 VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQ 943

  Fly   484 NHAERVCDMALDMVDAITDLKDPSTGQHL-----RIRVGVHSGAVVAGIVGLKMPRYCLFGDTVN 543
            .||..:.:|:||::.|:...:    .:|:     |||:|:|||..|||:|||.||||||||||||
Human   944 RHAAEIANMSLDILSAVGTFR----MRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVN 1004

  Fly   544 TASRMESTSIAMKVHISESTKVL---IGPNYKIIERGEIDVKGKGTMGTYWLEERE--NR---LP 600
            ||||||||.:..::|::.||..:   :...|::..||..::||||...|:||..|.  |:   .|
Human  1005 TASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKP 1069

  Fly   601 LQLTAALQVHPLS--PVPPTPTPKTKAIMP 628
            ..|......|.:|  .:||....|.:...|
Human  1070 PDLQPGSSNHGISLQEIPPERRRKLEKARP 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	31/190 (16%)
		HNOBA	201..404	CDD:462234	42/209 (20%)
		CYCc	383..571	CDD:214485	92/200 (46%)
		PHA03307	794..>955	CDD:223039
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945	58/356 (16%)
		HNOBA	<820..865	CDD:462234	18/57 (32%)
		CYCc	846..1036	CDD:214485	90/195 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1065..1103		8/35 (23%)