DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	384	Identity:	132/384 - (34%)
Similarity:	192/384 - (50%)	Gaps:	63/384 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 QTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEP-----------EKSLRLKGQMVYMEN 312
            |.|:.|....:.|...|...:.|.|:|      .:|.:|           ||.|.:  .::....
Human   671 QEIILRKETFYTLSCRDRNEKIFRVEN------SNGMKPFRPDLFLETAEEKELEV--YLLVKNC 727

  Fly   313 WRMIMFLGTPVMPDLTSLITT-----GLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSK 372
            |..    .....||...:.||     ||:      ||...:..:....:.::|     ..:....
Human   728 WEE----DPEKRPDFKKIETTLAKIFGLF------HDQKNESYMDTLIRRLQL-----YSRNLEH 777

  Fly   373 KLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRI 437
            .:||..:|...|..|.|.|.:.::|:.|...|:  |......|:::.|:|.|||||.||.||...
Human   778 LVEERTQLYKAERDRADRLNFMLLPRLVVKSLK--EKGFVEPELYEEVTIYFSDIVGFTTICKYS 840

  Fly   438 TPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDAN-HAERVCDMALDMVDAIT 501
            ||||||.|||.:|..||.:.:.:.|||||||||||||.:|.|.::.| ||..:..|||:::..:.
Human   841 TPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMG 905

  Fly   502 DLK-DPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKV 565
            ..: :...|..:.||:|||||...||:||:|||||||||||||||||||||.:.:::|:|.||..
Human   906 TFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIA 970

  Fly   566 LIGPN-----YKIIERGEIDVKGKGTMGTYWLE-ERENRLPLQLTAALQVHPLSPVPPT 618
            ::...     |::  |||..:||:|...||||. .::.:..|            |.|||
Human   971 ILKRTECQFLYEV--RGETYLKGRGNETTYWLTGMKDQKFNL------------PTPPT 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	32/160 (20%)
		CYCc	383..571	CDD:214485	90/194 (46%)
		Herpes_ICP4_C	794..>955	CDD:332854
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364
		PK_GC-C	480..750	CDD:270946	18/90 (20%)
		Pkinase_Tyr	502..745	CDD:285015	17/85 (20%)
		CYCc	788..979	CDD:214485	90/192 (47%)
		Guanylate_cyc	815..1002	CDD:278633	93/188 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810