Protein Alignment Gyc88E and GUCY1B1

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 94/504 - (18%)
• Similarity: 164/504 - (32%)
• Gaps: 191/504 - (37%)

  Fly   118 APQFHR-----SSHVTPSQQQRIEQAFGPAPVSQSQPQNGSYIQYNEPSTSVASTTT-------- 169
            |||:.|     |.|:|||        :..||    .|.....::|..|...:....|
Human   232 APQYSRLFPNASQHITPS--------YNYAP----NPDKHWIMRYTGPMKPIHMEFTNMLQRKRL 284

  Fly   170 -SFYSPNES-EPVFTHAISFKPNEPEN--------------------GQKAREQLEL-------- 204
             :..|.::| |.::...:  :..|.:|                    |:....:.::
Human   285 QTLMSVDDSMETIYNMLV--ETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRG 347

  Fly   205 --LDSGKINE---INQSKVPTTIELPPNCKLFQYSWVLDGIPRTLLVPMPMDA--------TEED 256
              :::|.:|.   :|....||.:::..          ||       :|..||.        ||..
Human   348 PNVEAGCLNPHIVLNIDLAPTILDIAG----------LD-------IPADMDGKSILKLLDTERP 395

  Fly   257 VKAM-LPKTLEM--DSNLFNNAR---PRDELPVLSFPNGTVPN----------------VEMIGP 299
            |... |.|.:.:  ||.|....:   .||...|.:.....:|.                .|.:|.
Human   396 VNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACEQLGQ 460

  Fly   300 KVQ---------------QPMLVN---------PKQFNRIMRRREMRQQLEA----SG--RLPLA 334
            |.|               .||.:.         ||.:.         |..||    ||  :|.||
Human   461 KWQCVEDATGKLKLHKCKGPMRLGGSRALSNLVPKYYG---------QGSEACTCDSGDYKLSLA 516

  Fly   335 -RQKYLHESRHLHALKRKRGL-------DGRFDNTKTAESSSMVSSTTSPRKLKRRNRLPG--EE 389
             |:|.|.:.::..:..|.|.:       |||..:....:::       .||.|.:|: .||  |:
Human   517 GRRKKLFKKKYKASYVRSRSIRSVAIEVDGRVYHVGLGDAA-------QPRNLTKRH-WPGAPED 573

  Fly   390 TSD------SSSIVLP-----SPVEIQPKGGIV--NSSMPSTSTGY--INNGMDHQTDYIEH--- 436
            ..|      |.:..||     :|:::..:...:  |.::......|  :....||:. :|:|
Human   574 QDDKDGGDFSGTGGLPDYSAANPIKVTHRRCYILENDTVQCDLDLYKSLQAWKDHKL-HIDHEIE 637

  Fly   437 --QQPMSTYDQYHDHVQYIAPD----GNVNYHNNHDNGVDLTGSDGQSF 479
              |..:....:...|::...|:    ..::||..|...:...||....|
Human   638 TLQNKIKNLREVRGHLKKKRPEECDCHKISYHTQHKGRLKHRGSSLHPF 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	14/49 (29%)
		HNOBA	201..404	CDD:462234	58/296 (20%)
		CYCc	383..571	CDD:214485	23/123 (19%)
		PHA03307	794..>955	CDD:223039
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233
		HNOBA	207..449	CDD:462234	43/247 (17%)
		Guanylate_cyc	455..648	CDD:425528	43/210 (20%)